公开(公告)号：US11072795B2

公开(公告)日：2021-07-27

申请号：US16345487

申请日：2017-10-16

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Uttam Surana ,  Dave Keng Boon Wee ,  Jing Lin ,  Bing Lim

IPC: C12N15/11 ,  C12N15/113 ,  A61P35/00 ,  A61K9/00 ,  A61K31/7088 ,  A61K45/06 ,  C12Q1/6886 ,  A61K31/7125 ,  A61K31/712

Abstract: The present invention relates to antisense oligonucleotides for modulating the activity of glycine decarboxylase (GLDC). In particular, the present invention relates to antisense oligonucleotides capable of inducing exon skipping of RNA. Also claimed are pharmaceutical compositions, kits and methods of treating cancer and inducing exon-skipping using said antisense oligonucleotides. In addition, a method for aiding the categorising or determining prognosis of a cancer or in selecting a therapeutic strategy for a patient with cancer, based on assessing the level of GLDC nucleic acid, protein or activity in a sample derived from the patient is provided.

公开(公告)号：US12188016B2

公开(公告)日：2025-01-07

申请号：US16626395

申请日：2018-06-27

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  LION TCR PTE. LTD.

Inventor： Ernest Guccione ,  Dave Keng Boon Wee ,  Antonio Bertoletti

IPC: C12N15/11 ,  A61K31/7088 ,  A61K35/17 ,  A61P35/00 ,  C12N15/113

Abstract: The present invention relates to antisense oligonucleotides for modulating the function of a T cell, including antisense oligonucleotides that hybridise to IFN-γ, granzyme, perforin 1, PD-1, PRDM1, PD-L1, CD40LG, NDFIP1, PDCD1 LG2, REL, BTLA, CD80, CD160, CD244, LAG3, TIGIT, ADORA2A & TIM-3 RNAs. In particular, the present invention relates to antisense oligonucleotides capable of inducing exon skipping of RNA. Also claimed is a method for further modifying the specificity of said T-cell by providing for a T cell receptor gene.