公开(公告)号：US11376256B2

公开(公告)日：2022-07-05

申请号：US16039916

申请日：2018-07-19

Applicant: Agency for Science, Technology and Research

Inventor： Zhenxun Wang ,  Wai Leong Tam ,  Lian Yee Yip ,  Ying Swan Ho ,  Zhengwei Wu ,  Bing Lim

IPC: A61K31/52 ,  A61P35/04 ,  A61K31/7105 ,  A61K31/67 ,  C12Q1/6886

Abstract: The present specification relates generally to a therapeutic protocol for treating a subject having cancer. Taught herein is a method of treating cancer or reducing the risk of recurrence of cancer in a subject following an anti-cancer therapy.

公开(公告)号：US11072795B2

公开(公告)日：2021-07-27

申请号：US16345487

申请日：2017-10-16

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Uttam Surana ,  Dave Keng Boon Wee ,  Jing Lin ,  Bing Lim

IPC: C12N15/11 ,  C12N15/113 ,  A61P35/00 ,  A61K9/00 ,  A61K31/7088 ,  A61K45/06 ,  C12Q1/6886 ,  A61K31/7125 ,  A61K31/712

Abstract: The present invention relates to antisense oligonucleotides for modulating the activity of glycine decarboxylase (GLDC). In particular, the present invention relates to antisense oligonucleotides capable of inducing exon skipping of RNA. Also claimed are pharmaceutical compositions, kits and methods of treating cancer and inducing exon-skipping using said antisense oligonucleotides. In addition, a method for aiding the categorising or determining prognosis of a cancer or in selecting a therapeutic strategy for a patient with cancer, based on assessing the level of GLDC nucleic acid, protein or activity in a sample derived from the patient is provided.

公开(公告)号：US20200022984A1

公开(公告)日：2020-01-23

申请号：US16039916

申请日：2018-07-19

Applicant: Agency for Science, Technology and Research

Inventor： Zhenxun Wang ,  Wai Leong Tam ,  Lian Yee Yip ,  Ying Swan Ho ,  Zhengwei Wu ,  Bing Lim

IPC: A61K31/52 ,  A61P35/04 ,  C12Q1/6886 ,  A61K31/67 ,  A61K31/7105

Abstract: The present specification relates generally to a therapeutic protocol for treating a subject having cancer. Taught herein is a method of treating cancer or reducing the risk of recurrence of cancer in a subject following an anti-cancer therapy.

公开(公告)号：US11180733B2

公开(公告)日：2021-11-23

申请号：US16315624

申请日：2017-07-04

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Tong Ming Liu ,  Bing Lim ,  Pin Li

IPC: C12N5/0775 ,  A61K35/28 ,  C12N5/074

Abstract: The present disclosure provides a method of generating mature mesenchymal stem cells and the cell culture medium used in such method. Also disclosed herein include a mesenchymal stem cell culture obtained by the method as disclosed herein, and uses thereof.

公开(公告)号：US11872230B2

公开(公告)日：2024-01-16

申请号：US17745292

申请日：2022-05-16

Applicant: Agency for Science, Technology and Research

Inventor： Zhenxun Wang ,  Wai Leong Tam ,  Lian Yee Yip ,  Ying Swan Ho ,  Zhengwei Wu ,  Bing Lim

IPC: C12Q1/6886 ,  A61K31/52 ,  A61P35/04 ,  A61K31/7105 ,  A61K31/67

CPC classification number: A61K31/52 ,  A61K31/67 ,  A61K31/7105 ,  A61P35/04 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: The present invention relates generally to a therapeutic protocol for treating a subject having cancer. Taught herein is a method of treating cancer or reducing the risk of recurrence of cancer in a subject following an anti-cancer therapy.

公开(公告)号：US20220280520A1

公开(公告)日：2022-09-08

申请号：US17745292

申请日：2022-05-16

Applicant: Agency for Science, Technology and Research

Inventor： Zhenxun Wang ,  Wai Leong Tam ,  Lian Yee Yip ,  Ying Swan Ho ,  Zhengwei Wu ,  Bing Lim

IPC: A61K31/52 ,  A61P35/04 ,  A61K31/7105 ,  A61K31/67 ,  C12Q1/6886

Abstract: The present invention relates generally to a therapeutic protocol for treating a subject having cancer. Taught herein is a method of treating cancer or reducing the risk of recurrence of cancer in a subject following an anti-cancer therapy.