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公开(公告)号：US20220098682A1
公开(公告)日：2022-03-31
申请号：US17423010
申请日：2020-01-14
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Ee Chee Ren , Hui Ling Ko
Abstract: A cell comprising: a nucleotide sequence encoding a Hepatitis B Virus (HBV) operably linked to a promoter; two nucleotide sequences each encoding an isoform of HNF4α; and a nucleotide sequence encoding a repressor of HBV transcription, wherein said nucleotide sequence is mutated to decrease or silence expression of the repressor.
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