公开(公告)号：US20140271902A1

公开(公告)日：2014-09-18

申请号：US14292734

申请日：2014-05-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi KURISAWA ,  Shengyong NG ,  Joo Eun CHUNG

IPC: A61K9/16 ,  A61K31/4706 ,  C07K16/18 ,  A61K38/48

CPC classification number: A61K9/1617 ,  A61K9/10 ,  A61K9/1652 ,  A61K31/353 ,  A61K31/4706 ,  A61K31/7048 ,  A61K31/728 ,  A61K38/482 ,  A61K47/61 ,  C07K16/18 ,  A61K2300/00

Abstract: There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. There is also provided a therapeutic formulation comprising such a suspension and methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.

Abstract translation: 目前提供了一种不混溶性颗粒悬浮于溶液中，其中颗粒包含生物活性剂的附聚物; 和多个透明质酸和类黄酮的缀合物，其中颗粒直径平均为约15nm至约300nm，并且其中生物活性剂通过类黄酮可释放地保留在颗粒中。 还提供了包含这种悬浮液的治疗制剂和使用悬浮液和治疗剂型的方法，包括将生物活性剂递送至细胞并用于治疗包括癌症的疾病。