公开(公告)号：US20160213787A1

公开(公告)日：2016-07-28

申请号：US14916559

申请日：2014-09-01

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi KURISAWA ,  Ki Hyun BAE

IPC: A61K47/48 ,  A61K9/06 ,  A61Q19/00 ,  A61K8/73 ,  A61K8/49 ,  A61K9/00 ,  A61K31/353 ,  A61K8/04

Abstract: There is provided polymer-flavonoid conjugates. Flavonoid-grafted and flavonoid-terminated polymer conjugates are disclosed according to the invention. The linkage of flavonoids to the polymers has been achieved via thiol linkages. The inventive processes allow for making of the conjugates in high yield avoiding complex purification steps. The conjugates can be easily autoxidized to hydrogels with uses in many biomedical applications where a higher stability of the flavonoid is necessary. The hydrogels can be potentially used as viscosupplement, anti-adhesion film or dermal filler.

Abstract translation: 提供了聚合物 - 类黄酮轭合物。 根据本发明公开了类黄酮接枝和类黄酮封端的聚合物缀合物。 黄酮与聚合物的连接已经通过硫醇键实现。 本发明的方法允许以高产率制备缀合物，避免了复杂的纯化步骤。 缀合物可以容易地自动氧化成水凝胶，其用途在许多生物医学应用中，其中黄酮类化合物的稳定性更高。 水凝胶可以用作粘合补充剂，抗粘连膜或真皮填料。

公开(公告)号：US20140271902A1

公开(公告)日：2014-09-18

申请号：US14292734

申请日：2014-05-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi KURISAWA ,  Shengyong NG ,  Joo Eun CHUNG

IPC: A61K9/16 ,  A61K31/4706 ,  C07K16/18 ,  A61K38/48

CPC classification number: A61K9/1617 ,  A61K9/10 ,  A61K9/1652 ,  A61K31/353 ,  A61K31/4706 ,  A61K31/7048 ,  A61K31/728 ,  A61K38/482 ,  A61K47/61 ,  C07K16/18 ,  A61K2300/00

Abstract: There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. There is also provided a therapeutic formulation comprising such a suspension and methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.

Abstract translation: 目前提供了一种不混溶性颗粒悬浮于溶液中，其中颗粒包含生物活性剂的附聚物; 和多个透明质酸和类黄酮的缀合物，其中颗粒直径平均为约15nm至约300nm，并且其中生物活性剂通过类黄酮可释放地保留在颗粒中。 还提供了包含这种悬浮液的治疗制剂和使用悬浮液和治疗剂型的方法，包括将生物活性剂递送至细胞并用于治疗包括癌症的疾病。

公开(公告)号：US20170258926A1

公开(公告)日：2017-09-14

申请号：US15309675

申请日：2015-05-08

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi KURISAWA ,  Yongvongsoontorn NUNNARPAS ,  Jackie Y. YING ,  Joo Eun CHUNG ,  Ki Hyun BAE ,  Min-han TAN ,  Esther LEE

IPC: A61K9/127 ,  A61K31/704 ,  A61K31/353 ,  C08G65/332 ,  A61K9/107 ,  A61K31/404 ,  C07D405/14

CPC classification number: A61K31/404 ,  A61K9/107 ,  A61K31/353 ,  A61K31/704 ,  A61K47/10 ,  A61K47/48215 ,  A61K47/60 ,  B82Y5/00 ,  C08G65/331 ,  C08G65/3315 ,  C08G65/3317 ,  C08G65/3318 ,  C08G65/332 ,  C08G65/3326 ,  C08G65/3328 ,  C08G65/33396 ,  C08L1/02 ,  C08L3/02 ,  C08L5/00 ,  C08L5/02 ,  C08L5/16 ,  C08L89/00 ,  C08L2203/02

Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.

公开(公告)号：US20170216446A1

公开(公告)日：2017-08-03

申请号：US15308725

申请日：2015-05-15

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi KURISAWA ,  Fan LEE

IPC: A61K47/48 ,  A61K31/353 ,  A61K31/728 ,  C08B37/00

Abstract: There is provided a polymer-flavonoid conjugate, or a pharmaceutically acceptable salt thereof, uses thereof, and methods of making thereof. The disclosed polymer-flavonoid conjugates may be useful in the therapeutic and/or prophylactic treatment of a joint condition in a subject.

公开(公告)号：US20160145580A1

公开(公告)日：2016-05-26

申请号：US14900080

申请日：2014-06-18

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi KURISAWA ,  Atsushi YAMASHITA

IPC: C12N5/09

CPC classification number: C12N5/0693 ,  C12N5/0695 ,  C12N2503/02 ,  C12N2533/80 ,  G01N33/5011

Abstract: There is provided a method for culturing a population of cancer stem cells. The method comprises introducing the cancer stem cells on or in a cell culture substrate, the cell culture substrate being in the form of a gel comprising a conjugate of a glycosaminoglycan and a substituted phenalkylamine.

Abstract translation: 提供了一种培养癌症干细胞群体的方法。 该方法包括将癌干细胞引入细胞培养基质上或细胞培养底物中，细胞培养基质为包含糖胺聚糖和取代的苯烷基胺的缀合物的凝胶形式。