公开(公告)号：US20240110241A1

公开(公告)日：2024-04-04

申请号：US18256303

申请日：2021-12-07

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Lai Guan Ng ,  Shu Feng Melissa Ng ,  De Li Leonard Tan ,  Florent Benoit Claude Ginhoux

IPC: C12Q1/6881

CPC classification number: C12Q1/6881 ,  C12Q2600/158 ,  G01N2800/52 ,  G01N2800/56

Abstract: The invention relates to a method of detecting and/or characterising an immunosuppressive neutrophil comprising determining and/or measuring the expression of one or more anti-apoptotic markers in a neutrophil population. In an embodiment, the immunosuppressive neutrophil is a polymorphonuclear myeloid-derived suppressor cell (PMNMDSC) and the anti-apoptotic marker is TNF-related apoptosis-inducing ligand (TRAIL)-receptor 3 (TRAILR3/TNFRSF10C) and/or decoy TNF-related apoptosis-inducing ligand (TRAIL)-receptor (dcTRAILR1). Also disclosed are methods of evaluating the progression of a proliferative disease in a subject, methods of evaluating the efficacy of a treatment regimen for a proliferative disease in a subject, methods of treating a proliferative disease in a subject, and kits thereof.