公开(公告)号：US11834430B2

公开(公告)日：2023-12-05

申请号：US16646693

申请日：2018-09-12

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Soo Yei Ho ,  Anders Poulsen ,  Sum Wai Eldwin Tan ,  Shi Hua Ang ,  Thomas Hugo Keller

IPC: C07D401/04 ,  C07D231/12 ,  C07D233/12 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  A61P35/00 ,  C07D233/06 ,  C07D233/60 ,  C07D261/08 ,  C07D277/24 ,  C07D403/12

CPC classification number: C07D401/04 ,  A61P35/00 ,  C07D231/12 ,  C07D233/06 ,  C07D233/60 ,  C07D249/08 ,  C07D261/08 ,  C07D277/24 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

Abstract: The present invention relates to compounds of general Formula (I), and/or tautomers, enantiomers, solvates, hydrates, and pharmaceutically acceptable salts thereof. The present invention also relates to compounds of Formula (I) for use in therapy, methods of treating isoprenylcysteine carboxyl methyltransferase (ICMT) related disorders or uses of compounds of Formula (I) in the manufacture of a medicament for the treatment of ICMT-related disorders, wherein the disorder is cancer and/or progeria. The present invention further relates to processes for synthesizing compounds of Formula (I).

公开(公告)号：US20210130317A1

公开(公告)日：2021-05-06

申请号：US16646693

申请日：2018-09-12

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Soo Yei Ho ,  Anders Poulsen ,  Sum Wai Eldwin Tan ,  Shi Hua Ang ,  Thomas Hugo Keller

IPC: C07D401/04 ,  C07D249/08 ,  C07D233/60 ,  C07D277/24 ,  C07D401/12 ,  C07D231/12 ,  C07D233/06 ,  C07D261/08 ,  C07D401/14 ,  C07D403/12 ,  A61P35/00

Abstract: The present invention relates to compounds of general Formula (I), and/or tautomers, enantiomers, solvates, hydrates, and pharmaceutically acceptable salts thereof. The present invention also relates to compounds of Formula (I) for use in therapy, methods of treating isoprenylcysteine carboxyl methyltransferase (ICMT) related disorders or uses of compounds of Formula (I) in the manufacture of a medicament for the treatment of ICMT-related disorders, wherein the disorder is cancer and/or progeria. The present invention further relates to processes for synthesizing compounds of Formula (I).