-
公开(公告)号：US20210205451A1
公开(公告)日：2021-07-08
申请号：US17121229
申请日：2020-12-14
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , Nicholas Stuart Wilson , David Adam Savitsky , Mark Arthur Findeis , Dennis John Underwood , Jean-Marie Cuillerot , Igor Proscurshim , Olga Shebanova
IPC分类号： A61K39/395 , C07K16/28 , A61P11/00 , A61P35/04
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
-
公开(公告)号：US11013802B2
公开(公告)日：2021-05-25
申请号：US15834290
申请日：2017-12-07
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , Nicholas Stuart Wilson , David Adam Savitsky , Mark Arthur Findeis , Dennis John Underwood , Jean-Marie Cuillerot , Igor Proscurshim , Olga Shebanova
IPC分类号： C07K16/28 , A61K39/395 , A61P11/00 , A61P35/04 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
-
公开(公告)号：US10479833B2
公开(公告)日：2019-11-19
申请号：US16165833
申请日：2018-10-19
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , David Adam Savitsky , Nicholas Stuart Wilson
IPC分类号： C07K16/28 , A61K39/395 , A61K47/68 , A61K51/10 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
-
公开(公告)号：US11267889B2
公开(公告)日：2022-03-08
申请号：US16858195
申请日：2020-04-24
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc Van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , David Adam Savitsky , Nicholas Stuart Wilson
摘要： The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
-
公开(公告)号：US10577426B2
公开(公告)日：2020-03-03
申请号：US15962673
申请日：2018-04-25
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Ana M. Gonzalez , Nicholas S. Wilson , Dennis J. Underwood , Volker Seibert , Olivier Léger , Marc Van Dijk , Roberta Zappasodi , Taha Merghoub , Jedd David Wolchok , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
-
公开(公告)号：US20180185481A1
公开(公告)日：2018-07-05
申请号：US15834290
申请日：2017-12-07
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , Nicholas Stuart Wilson , David Adam Savitsky , Mark Arthur Findeis , Dennis John Underwood , Jean-Marie Cuillerot , Igor Proscurshim , Olga Shebanova
IPC分类号： A61K39/395 , A61P11/00 , A61P35/04
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
-
公开(公告)号：US20160368989A1
公开(公告)日：2016-12-22
申请号：US15166305
申请日：2016-05-27
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , David Adam Savitsky , Mark Arthur Findeis , Nicholas Stuart Wilson
CPC分类号： C07K16/2818 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/283 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
摘要翻译： 本公开提供特异性结合人CTLA-4并拮抗CTLA-4功能的抗体。 还提供了包含这些抗体的药物组合物，编码这些抗体的核酸，用于制备这些抗体的表达载体和宿主细胞，以及使用这些抗体治疗受试者的方法。
-
公开(公告)号：US11345755B2
公开(公告)日：2022-05-31
申请号：US16858193
申请日：2020-04-24
申请人： AGENUS INC. , LUDWIG INSTITUTE FOR CANCER RESEARCH LTD , MEMORIAL SLOAN KETTERING CANCER CENTER
发明人： Marc Van Dijk , Cornelia Anne Mundt , Gerd Ritter , Jedd David Wolchok , Taha Merghoub , Roberta Zappasodi , Rikke Bæk Holmgaard , David Schaer , David Adam Savitsky , Nicholas Stuart Wilson
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
-
公开(公告)号：US10912831B1
公开(公告)日：2021-02-09
申请号：US17030650
申请日：2020-09-24
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： Marc van Dijk , Cornelia Anne Mundt , Gerd Ritter , David Schaer , Jedd David Wolchok , Taha Merghoub , Nicholas Stuart Wilson , David Adam Savitsky , Mark Arthur Findeis , Dennis John Underwood , Jean-Marie Cuillerot , Igor Proscurshim , Olga Shebanova
IPC分类号： A61K39/395 , C07K16/28 , A61P11/00 , A61P35/04 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
-
公开(公告)号：US10800849B2
公开(公告)日：2020-10-13
申请号：US15962752
申请日：2018-04-25
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Ana M. Gonzalez , Nicholas S. Wilson , Dennis J. Underwood , Volker Seibert , Olivier Léger , Marc Van Dijk , Roberta Zappasodi , Taha Merghoub , Jedd David Wolchok , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.035 秒)
