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公开(公告)号：US11447557B2
公开(公告)日：2022-09-20
申请号：US15781043
申请日：2016-12-02
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Nicholas S. Wilson , Jeremy D. Waight , Gerd Ritter , David Schaer , Daniel Hirschhorn-Cymerman , Taha Merghoub , Ekaterina V. Breous-Nystrom , Volker Seibert , Takemasa Tsuji , Olivier Léger , Dennis J. Underwood , Marc Van Dijk
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06
摘要： The present disclosure provides multispecific (e.g., bispecific) antibodies that specifically bind to human GITR and/or human OX40 as well as compositions comprising such antibodies. In a specific aspect, the multispecific antibodies specifically bind to human GITR and OX40 and modulate GITR and/or OX40 activity, e.g., enhance, activate, or induce GITR and/or OX40 activity, or reduce, deactivate, or inhibit GITR and/or OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., enhances, activates, or induces GITR and/or OX40 activity. Also provided are methods for treating autoimmune or inflammatory diseases or disorders, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., reduces, deactivates, or inhibits GITR and/or OX40 activity.
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公开(公告)号：US10577426B2
公开(公告)日：2020-03-03
申请号：US15962673
申请日：2018-04-25
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Ana M. Gonzalez , Nicholas S. Wilson , Dennis J. Underwood , Volker Seibert , Olivier Léger , Marc Van Dijk , Roberta Zappasodi , Taha Merghoub , Jedd David Wolchok , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
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公开(公告)号：US10800849B2
公开(公告)日：2020-10-13
申请号：US15962752
申请日：2018-04-25
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Ana M. Gonzalez , Nicholas S. Wilson , Dennis J. Underwood , Volker Seibert , Olivier Léger , Marc Van Dijk , Roberta Zappasodi , Taha Merghoub , Jedd David Wolchok , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
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公开(公告)号：US10280226B2
公开(公告)日：2019-05-07
申请号：US16175453
申请日：2018-10-30
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Volker Seibert , Olivier Léger , Marc Van Dijk , Taha Merghoub , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
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公开(公告)号：US10155818B2
公开(公告)日：2018-12-18
申请号：US14724452
申请日：2015-05-28
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Volker Seibert , Olivier Léger , Marc Van Dijk , Taha Merghoub , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
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公开(公告)号：US20230039577A1
公开(公告)日：2023-02-09
申请号：US17808248
申请日：2022-06-22
申请人： AGENUS INC. , Ludwig Institute for Cancer Research Ltd. , Memorial Sloan-Kettering Cancer Center
发明人： Ana M. GONZALEZ , Nicholas S. Wilson , Dennis J. Underwood , Volker Seibert , Olivier Léger , Marc Van Dijk , Roberta Zappasodi , Taha Merghoub , Jedd David Wolchok , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
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公开(公告)号：US10829559B2
公开(公告)日：2020-11-10
申请号：US16355268
申请日：2019-03-15
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Volker Seibert , Olivier Léger , Marc Van Dijk , Taha Merghoub , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
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公开(公告)号：US20150368349A1
公开(公告)日：2015-12-24
申请号：US14724452
申请日：2015-05-28
申请人： 4-Antibody AG , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Caner Research Ltd.
发明人： Ana M. GONZALEZ , Nicholas S. Wilson , Dennis J. Underwood , Volker Seibert , Olivier Léger , Marc van Dijk , Roberta Zappasodi , Taha Merghoub , Jedd David Wolchok , David Schaer , Gerd Ritter , Takemasa Tsuji
IPC分类号： C07K16/28 , A61K35/17 , A61K45/06 , G01N33/50 , A61K39/395
CPC分类号： C07K16/2878 , A61K35/17 , A61K2039/507 , C07K16/2809 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/502 , G01N2333/70578 , Y02A50/386
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
摘要翻译： 本公开提供了特异性结合人糖皮质激素诱导的TNFR家族相关受体（GITR）的抗体和包含此类抗体的组合物。 在具体方面，抗体与人GITR特异性结合并利用这种抗体调节GITR活性，例如增强，激活或诱导GITR活性。 本公开还提供了通过施用特异性结合人GITR并调节GITR活性的抗体（例如增强，激活或诱导GITR活性）来治疗疾病如癌症和感染性疾病的方法。
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