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公开(公告)号：US10414740B2
公开(公告)日：2019-09-17
申请号：US15996723
申请日：2018-06-04
发明人： Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
IPC分类号： C07D285/135 , C07D417/14 , C07D285/12 , C07D417/12 , C07D471/04
摘要： Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
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公开(公告)号：US10029987B2
公开(公告)日：2018-07-24
申请号：US15412976
申请日：2017-01-23
IPC分类号： A61K31/47 , A61K31/551 , C07D215/36 , C07D401/12 , C07D403/12 , C07D417/12
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：US09512107B2
公开(公告)日：2016-12-06
申请号：US15173519
申请日：2016-06-03
发明人： Giovanni Cianchetta , Byron DeLaBarre , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan , Tao Guo , Li Zhang
IPC分类号： C07D401/14 , C07D251/18 , A61K31/53
CPC分类号： C07D401/14 , A61K31/53 , A61K31/5377 , C07D251/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D493/08
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
摘要翻译： 提供的是用于治疗癌症的化合物和治疗癌症的方法，包括向有需要的受试者施用本文所述的化合物。
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公开(公告)号：US20150291576A1
公开(公告)日：2015-10-15
申请号：US14646634
申请日：2013-11-21
发明人： Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Yongsheng Chen
IPC分类号： C07D417/14 , C07D285/135
CPC分类号： C07D417/14 , C07D285/135
摘要： Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors for treating cancers thereof are also provided.
摘要翻译： 提供可抑制谷氨酰胺酶的式（I）化合物。 还提供了包含这些化合物的药物组合物和用作治疗其癌症的谷氨酰胺酶抑制剂。
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公开(公告)号：US11505538B1
公开(公告)日：2022-11-22
申请号：US16905736
申请日：2020-06-18
发明人： Giovanni Cianchetta , Byron DeLaBarre , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan , Tao Guo , Li Zhang
IPC分类号： C07D251/18 , A61K31/53 , C07D401/14 , A61K31/5377 , C07D401/12 , C07D413/14 , C07D405/14 , C07D403/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D493/08
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
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公开(公告)号：US10689375B2
公开(公告)日：2020-06-23
申请号：US16107220
申请日：2018-08-21
发明人： Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Yongsheng Chen
IPC分类号： A61K31/433 , C07D417/14 , C07D285/135
摘要： Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
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公开(公告)号：US09856279B2
公开(公告)日：2018-01-02
申请号：US15130358
申请日：2016-04-15
发明人： Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy M. Travins , Shunqi Yan , Zhixiong Ye
IPC分类号： C07D401/04 , C07D401/14 , C07D407/14 , C07D413/14 , C07D471/04 , A61K31/496 , C07F9/6509 , C07D405/14 , C07D213/85 , C07D401/12 , C07D405/12 , C07D409/14 , C07D417/14 , C07F9/6558 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , C07D487/04 , C07D498/04 , A61K31/5377 , A61K31/675
CPC分类号： C07F9/650952 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/675 , C07D213/85 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07F9/65583
摘要： Provided are piperazine compounds of Formula I useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described here.
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公开(公告)号：US20170369481A1
公开(公告)日：2017-12-28
申请号：US15645621
申请日：2017-07-10
IPC分类号： C07D413/12 , C07D265/36 , C07D265/18
CPC分类号： C07D413/12 , C07D265/18 , C07D265/36
摘要： Compounds and compositions comprising compounds that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that activate PKM2 in the treatment of cancer.
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公开(公告)号：US09732062B2
公开(公告)日：2017-08-15
申请号：US13735467
申请日：2013-01-07
发明人： Giovanni Cianchetta , Byron DeLaBarre , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan , Tao Guo , Li Zhang
IPC分类号： C07D251/18 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , A61K31/5377 , A61K31/53 , C07D403/04 , C07D413/04 , C07D417/04 , C07D493/08
CPC分类号： C07D401/14 , A61K31/53 , A61K31/5377 , C07D251/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D493/08
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
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公开(公告)号：US20170044139A1
公开(公告)日：2017-02-16
申请号：US15337683
申请日：2016-10-28
发明人： Giovanni Cianchetta , Byron DeLaBarre , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan , Tao Guo , Li Zhang
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61K31/53 , A61K31/5377 , C07D251/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D493/08
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
摘要翻译： 提供的是用于治疗癌症的化合物和治疗癌症的方法，包括向有需要的受试者施用本文所述的化合物。
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