公开(公告)号：US3872110A

公开(公告)日：1975-03-18

申请号：US24678172

申请日：1972-04-24

申请人： AJINOMOTO KK

发明人： ARIYOSHI YASUO ,  YAMATANI TETSUO ,  UCHIYAMA NOBORU ,  SATO NAOTAKE ,  TOI KOJI

IPC分类号： C07C55/02 ,  C07D307/66

CPC分类号： C07C59/245

摘要： The hydrochloride and hydrobromide of aspartic anhydride are obtained in high yields when the known reaction between one mole of aspartic acid and suitable halide dehydrating agents, such as phosphorus chlorides, is carried out in the presence of at least one mole of a lower alkanoic acid which provides at least a portion of the liquid reaction medium. The yield is further improved by adding the anhydride of the alkanoic acid to the reaction mixture.

摘要翻译： 当1摩尔天冬氨酸和合适的卤化物脱水剂如氯化磷之间的已知反应在至少1摩尔的低级链烷酸存在下进行时，天然碱酐的盐酸盐和氢溴酸盐以高产率获得， 提供至少一部分液体反应介质。 通过向反应混合物中加入链烷酸的酸酐进一步提高产率。

公开(公告)号：US3678026A

公开(公告)日：1972-07-18

申请号：US3678026D

申请日：1970-12-28

申请人： AJINOMOTO KK

发明人： ARIYOSHI YASUO ,  YAMATANI TETSUO ,  UCHIYAMA NOBORU ,  NAOTAKE SATO

IPC分类号： C07K5/072 ,  C07K5/075 ,  C07C103/52

CPC分类号： C07K5/0613

摘要： The lower alkyl esters of Alpha -L-aspartyl-L-phenylalanine, known artificial sweeteners, are separated from the bitter tasting Beta -isomers and other impurities by the low solubility of their adducts with certain aromatic carboxylic acids and phenols in water.

摘要翻译： 已知的人造甜味剂α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯通过与​​某些芳族羧酸和酚在水中的加合物的低溶解度与苦味β-异构体和其它杂质分离。

公开(公告)号：US3598838A

公开(公告)日：1971-08-10

申请号：US3598838D

申请日：1968-08-21

申请人： AJINOMOTO KK

发明人： TOI KOJI ,  NAKAYAMA NAOKO ,  AKASHI TAKEKAZU ,  UCHIYAMA NOBORU

IPC分类号： C07D207/16 ,  H01H35/34 ,  C07D27/04 ,  C07C61/00

CPC分类号： C07D207/16 ,  H01H35/34

摘要： PROLINE, GLYCINE, ALANINE, VALINE, PHENYLALANINE, METHIONINE, AND LYSINE FORM ADDUCTS WITH CHLORENDIC ACID, WHICH ARE INSOLUBLE OR ONLY SPARINGLY SOLUBLE IN WATER, AND MAY THEREBY BE SEPARATED FROM ALL OTHER AMINO ACIDS WHICH DO NOT FORM INSOLUBLE CHLORENDIC ACID SALTS UNDER THESE CONDITIONS.