公开(公告)号：US20160101088A1

公开(公告)日：2016-04-14

申请号：US14876826

申请日：2015-10-07

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yun-Hoon Choung ,  Yeon Ju Kim

IPC: A61K31/436 ,  A23L1/30 ,  A61K31/7036

CPC classification number: A61K31/436 ,  A23L33/10 ,  A61K31/7036

Abstract: A pharmaceutical or health food includes rapamycin as an active ingredient, the pharmaceutical or health food being applied for prevention, improvement, and treatment of ototoxic hearing loss caused by an aminoglycoside-based antibiotic, sudden sensorineural hearing loss, and noise induced hearing loss. The pharmaceutical or health food is also applied to a pharmaceutical composite preparation of an aminoglycoside-based antibiotic and rapamycin, the pharmaceutical composite preparation reducing a side effect of the aminoglycoside-based antibiotic.

Abstract translation: 药物或保健食品包括雷帕霉素作为活性成分，用于预防，改善和治疗由氨基糖苷类抗生素引起的耳毒性听力损失，突发性感觉神经性听力损失和噪声引起的听力损失的药物或保健食品。 药物或保健食品也适用于基于氨基糖苷类的抗生素和雷帕霉素的药物复合制剂，该药物复合制剂减少了基于氨基糖苷类的抗生素的副作用。

公开(公告)号：US11534473B2

公开(公告)日：2022-12-27

申请号：US16627113

申请日：2018-05-30

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yun-Hoon Choung ,  Young Sun Kim ,  Young-Joon Park

IPC: A61K36/87 ,  A23L33/105 ,  A23L33/00 ,  A61P27/16 ,  A61K9/00 ,  A61K31/05 ,  A61K36/16 ,  A61K36/258

Abstract: A composition for preventing or treating hearing loss, containing a Vitis vinifera leaf extract as an active ingredient, is disclosed. A pharmaceutical composition for preventing or treating hearing loss, containing the extract (a Vitis vinifera leaf extract) as an active ingredient, protects auditory hair cells in the cochlea and spiral ganglion cells from damage caused by noise and the like and effectively reduces the hearing threshold measured in the auditory nerves, thereby being usable as an agent for preventing or treating hearing loss.

公开(公告)号：US09925198B2

公开(公告)日：2018-03-27

申请号：US15208608

申请日：2016-07-13

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yun-Hoon Choung ,  Yeon Ju Kim

IPC: A61K31/56 ,  A23L33/10 ,  A61K31/282 ,  A61K31/555 ,  A61K31/7036

CPC classification number: A61K31/56 ,  A23L33/10 ,  A61K31/282 ,  A61K31/555 ,  A61K31/7036

Abstract: The present invention is related to a pharmaceutical composition and health food for preventing or treating hearing loss, wherein the pharmaceutical composition and health food contain carbenoxolone or its pharmaceutically acceptable salts as an effective component. More particularly, a composition including carbenoxolone or its pharmaceutically acceptable salts as an effective component is provided as a pharmaceutical composition for preventing or treating ototoxic hearing loss due to the carbenoxolone or its pharmaceutically acceptable salts prevent damages on auditory cells from ototoxic drugs such as cisplatin anticancer drugs, and the composition may be used as a drug for treating noise-induced hearing loss and age-related hearing loss, as well as ototoxic hearing loss.

公开(公告)号：US12011431B2

公开(公告)日：2024-06-18

申请号：US17265436

申请日：2019-08-06

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yun-Hoon Choung ,  Yeon Ju Kim

IPC: A61K31/352 ,  A61K31/202 ,  A61K45/06 ,  A61P27/16

CPC classification number: A61K31/352 ,  A61K31/202 ,  A61K45/06 ,  A61P27/16

Abstract: A pharmaceutical composition containing forskolin and retinoic acid as active ingredients which is suitable for preventing or treating sensorineural hearing loss is disclosed. A pharmaceutical composition containing forskolin and retinoic acid as active ingredients has an excellent effect of preventing, alleviating or treating hearing loss caused by ototoxic drugs during anticancer treatment, and thus is useful as a pharmaceutical composite preparation capable of reducing side effects of anticancer drugs and, additionally, as an agent for preventing or treating sensorineural hearing loss.

公开(公告)号：US10016400B2

公开(公告)日：2018-07-10

申请号：US14876826

申请日：2015-10-07

Applicant: AJOU UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION

Inventor： Yun-Hoon Choung ,  Yeon Ju Kim

IPC: A61K31/436 ,  A61K31/7036 ,  A23L33/10

CPC classification number: A61K31/436 ,  A23L33/10 ,  A61K31/7036

Abstract: A pharmaceutical or health food includes rapamycin as an active ingredient, the pharmaceutical or health food being applied for prevention, improvement, and treatment of ototoxic hearing loss caused by an aminoglycoside-based antibiotic, sudden sensorineural hearing loss, and noise induced hearing loss. The pharmaceutical or health food is also applied to a pharmaceutical composite preparation of an aminoglycoside-based antibiotic and rapamycin, the pharmaceutical composite preparation reducing a side effect of the aminoglycoside-based antibiotic.

公开(公告)号：US11376233B2

公开(公告)日：2022-07-05

申请号：US16604759

申请日：2018-04-10

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yun-Hoon Choung ,  Young Sun Kim ,  Young-Joon Park

IPC: A61K31/216 ,  A61P27/00 ,  A61K31/05 ,  A61K36/16 ,  A61K36/258 ,  A61K36/87

Abstract: The present invention relates to a pharmaceutical composition, containing sarpogrelate or a pharmaceutically acceptable salt thereof as an active ingredient, for preventing, alleviating, or treating sensorineural hearing loss. The sarporgrelate according to the present invention protects against hearing loss caused by noise through the suppression of auditory cell apoptosis and the expression increase of antioxidant enzyme in auditory cells, and thus can be advantageously used in the prevention and alleviation of sensorineural hearing loss.

公开(公告)号：US11185530B2

公开(公告)日：2021-11-30

申请号：US16488881

申请日：2018-03-09

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yun-Hoon Choung ,  Yun Yeong Lee ,  Oak-Sung Choo

IPC: A61K31/40 ,  A61P27/16 ,  A61K9/28

Abstract: The present invention relates to a composition for preventing or treating hearing loss, containing an HMG-CoA reductase inhibitor and, more specifically, to a composition for preventing or treating diabetes-mediated hearing loss, containing, as an active ingredient(s), one or more types selected from the group consisting of atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin. A pharmaceutical composition containing an HMG-CoA reductase inhibitor, according to the present invention, inhibits auditory cell death caused by diabetes, and thus is very useful as an agent for preventing or treating diabetes-mediated sensorineural hearing loss.