公开(公告)号：US09689019B2

公开(公告)日：2017-06-27

申请号：US13760450

申请日：2013-02-06

申请人： AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Woo Young Shim ,  Duc Toan Nguyen ,  Gwang Lee ,  Man Jeong Paik ,  Jae Ho Kim ,  Sang Mi Hyun ,  Ki Ryung Choi ,  Sung Su Park ,  Jin Seok Kang ,  Jeom Soon Shim ,  Tae-Hwan Shin ,  Geetika Phukan

IPC分类号： C12Q1/68 ,  C12Q1/02 ,  G01N33/50

CPC分类号： C12Q1/025 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158 ,  G01N33/5091 ,  G01N2800/40 ,  G01N2800/60

摘要： Disclosed is a biomarker composition for diagnosing the toxicity of nanoparticles, which shows a change in expression by exposure to the nanoparticles, the biomarker composition comprising at least one gene selected from the group consisting of aldehyde dehydrogenase, glutamic-pyruvate transaminase, glutamate dehydrogenase, glutamicoxaloacetic transaminase, glutamic acid decarboxylase and glutamate-ammonia ligase, and to a method for evaluating the toxicity of nanoparticles using the same. The biomarker is a gene marker having a high correlation with the toxicity of nanoparticles, and the use of the biomarker can determine whether nanoparticles have toxicity, with high detection sensitivity. Also, the method is useful in monitoring or evaluating the toxicity of nanoparticles by analyzing factors having a high correlation with toxicity of nanoparticles. Furthermore, the method can be effectively used as a tool for studying various diseases caused by exposure to nanoparticles or evaluating the effects of nanoparticles on health.

公开(公告)号：US20140024545A1

公开(公告)日：2014-01-23

申请号：US13760450

申请日：2013-02-06

申请人： AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Woo Young SHIM ,  Duc Toan Nguyen ,  Gwang Lee ,  Man Jeong Paik ,  Jae Ho Kim ,  Sang Mi Hyun ,  Ki Ryung Choi ,  Sung Su Park ,  Jin Seok Kang ,  Jeom Soon Shim

IPC分类号： C12Q1/02 ,  C12Q1/68

CPC分类号： C12Q1/025 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158 ,  G01N33/5091 ,  G01N2800/40 ,  G01N2800/60

摘要： The present invention relates to a biomarker composition for diagnosing the toxicity of nanoparticles, which shows a change in expression by exposure to the nanoparticles, the biomarker composition comprising at least one gene selected from the group consisting of aldehyde dehydrogenase, glutamic-pyruvate transaminase, glutamate dehydrogenase, glutamicoxaloacetic transaminase, glutamic acid decarboxylase and glutamate-ammonia ligase, and to a method for evaluating the toxicity of nanoparticles using the same. The biomarker is a gene marker having a high correlation with the toxicity of nanoparticles, and the use of the biomarker can determine whether nanoparticles have toxicity, with high detection sensitivity. Also, the method is useful in monitoring or evaluating the toxicity of nanoparticles by analyzing factors having a high correlation with toxicity of nanoparticles. Furthermore, the method can be effectively used as a tool for studying various diseases caused by exposure to nanoparticles or evaluating the effects of nanoparticles on health.

摘要翻译： 本发明涉及用于诊断纳米颗粒的毒性的生物标志物组合物，其通过暴露于纳米颗粒而显示出表达变化，所述生物标志物组合物包含至少一种选自醛脱氢酶，谷氨酸 - 丙酮酸转氨酶，谷氨酸 脱氢酶，谷氨酰氧乙酰转氨酶，谷氨酸脱羧酶和谷氨酸 - 氨连接酶，以及评价使用其的纳米粒子的毒性的方法。 生物标志物是与纳米颗粒的毒性高度相关的基因标记，并且使用生物标志物可以确定纳米颗粒是否具有毒性，具有高检测灵敏度。 此外，该方法通过分析与纳米颗粒的毒性高度相关的因素来监测或评估纳米颗粒的毒性是有用的。 此外，该方法可以有效地用作研究由纳米颗粒暴露或评估纳米颗粒对健康的影响而引起的各种疾病的工具。