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公开(公告)号：US20240226111A1
公开(公告)日：2024-07-11
申请号：US18440990
申请日：2024-02-14
发明人： Siyoung Yang
IPC分类号： A61K31/551 , A61P19/02 , C12N15/113
CPC分类号： A61K31/551 , A61P19/02 , C12N15/113 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/141 , C12N2310/531
摘要： The present disclosure relates to a composition for treating osteoarthritis or eliminating senescent cells, including K-7174 that targets zinc finger MIZ domain-containing protein 1 (Zmiz1) as an active ingredient, wherein suppression of overexpression of Zmiz1 found in osteoarthritis-induced joint tissues or mice as well as suppression of expression, due to binding between K-7174 and GATA whose expression is induced by the Zmiz1 overexpression, of joint destructing factors (Mmp3, Cox2) and senescence cell promoting factors (Glb1, p16) whose expressions are increased upon the overexpression have shown effects of decreasing the progression of osteoarthritis and promoting elimination of senescent cells, such that it is possible to provide a composition including the K-7174 as an active ingredient as a treatment for osteoarthritis or an agent for eliminating senescent cells.
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公开(公告)号：US12117455B2
公开(公告)日：2024-10-15
申请号：US17475753
申请日：2021-09-15
发明人： You-Sun Kim , Siyoung Yang
IPC分类号： C12Q1/6883 , G01N33/68
CPC分类号： G01N33/6893 , G01N2500/00 , G01N2800/105
摘要： Disclosed is the novel use of TRIM24 and RIP3 as biomarkers for diagnosing osteoarthritis, in which it is first identified that TRIM24 and RIP3 can be used as biomarkers for diagnosing osteoarthritis by confirming the tendency of TRIM24 expression to decrease and RIP3 expression to increase at the onset of osteoarthritis. These two proteins are useful in confirming the change in the expression level from the onset of osteoarthritis, thus enabling early diagnosis of osteoarthritis and effectively blocking the progression of osteoarthritis at an early stage.
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