公开(公告)号：US10308718B2

公开(公告)日：2019-06-04

申请号：US15867609

申请日：2018-01-10

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11339223B2

公开(公告)日：2022-05-24

申请号：US16058817

申请日：2018-08-08

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11208488B2

公开(公告)日：2021-12-28

申请号：US16134830

申请日：2018-09-18

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11186645B2

公开(公告)日：2021-11-30

申请号：US16741658

申请日：2020-01-13

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US12297277B2

公开(公告)日：2025-05-13

申请号：US17836707

申请日：2022-06-09

Applicant: Alector LLC

Inventor： Tina Schwabe ,  Michael Kurnellas ,  Arnon Rosenthal ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10428150B2

公开(公告)日：2019-10-01

申请号：US15999627

申请日：2018-08-20

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190085084A1

公开(公告)日：2019-03-21

申请号：US16134830

申请日：2018-09-18

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190062433A1

公开(公告)日：2019-02-28

申请号：US16058817

申请日：2018-08-08

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10087255B2

公开(公告)日：2018-10-02

申请号：US15285359

申请日：2016-10-04

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas

IPC: A61K39/395 ,  C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.