公开(公告)号：US12258398B2

公开(公告)日：2025-03-25

申请号：US17263534

申请日：2019-07-26

Applicant: Alector LLC

Inventor： Patricia Culp ,  Rashmi Bankoti ,  Helen Lam ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/00 ,  A61K47/68 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a Siglec-5 protein, e.g., human Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20250026827A1

公开(公告)日：2025-01-23

申请号：US18756198

申请日：2024-06-27

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a SIRPβ1 polypeptide, e.g., a human SIRPβ1, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US12186409B2

公开(公告)日：2025-01-07

申请号：US17088237

申请日：2020-11-03

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe

IPC: G01N33/543 ,  A61K49/00 ,  C07K16/28 ,  G01N21/64 ,  G01N33/533 ,  G01N33/542

Abstract: The present disclosure provides methods of screening for a sortilin binding antagonist. In some embodiments, the methods include incubating an agent with a sortilin protein and a sortilin ligand, where the sortilin protein and sortilin ligand are each attached to a member of a fluorescence donor/acceptor pair, exciting the fluorescence donor of the fluorescence donor/acceptor pair, and detecting fluorescence emitted by the fluorescence donor at a second wavelength and fluorescence emitted by the fluorescence acceptor at a third wavelength. A decrease in the ratio of the fluorescence emitted by the fluorescence acceptor at the third wavelength to the fluorescence emitted by the fluorescence donor at the second wavelength, as compared to the ratio in the absence of the agent, indicates that the agent is a sortilin binding antagonist.

公开(公告)号：US11667710B2

公开(公告)日：2023-06-06

申请号：US17016744

申请日：2020-09-10

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Kate Monroe ,  Seung-Joo Lee

IPC: C07K16/28 ,  G01N33/577 ,  G01N33/574 ,  A61P31/04 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  A61K45/06 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/574 ,  G01N33/577

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-9 protein, e.g., human Siglec-9 or a mammalian Siglec-9, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10676525B2

公开(公告)日：2020-06-09

申请号：US16054680

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Tina Schwabe ,  Eric Brown ,  Philip Kong ,  Ilaria Tassi ,  Seung-Joo Lee ,  Arnon Rosenthal ,  Robert Pejchal ,  Nels P. Nielson

IPC: C07K16/28 ,  A61P25/28 ,  A61K39/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10590198B2

公开(公告)日：2020-03-17

申请号：US15756043

申请日：2016-08-26

Applicant: Alector LLC

Inventor： Kate Monroe ,  Helen Lam ,  Arnon Rosenthal ,  Seung-Joo Lee ,  Francesca Avogadri-Connors ,  William Monteith

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00 ,  A61P37/02 ,  A61P25/00 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190315858A1

公开(公告)日：2019-10-17

申请号：US16382117

申请日：2019-04-11

Applicant: ALECTOR LLC

Inventor： Kate Monroe ,  Tina Schwabe ,  Francesca Avogadri-Connors ,  Ilaria Tassi ,  Helen Lam ,  Arnon Rosenthal

IPC: C07K16/28

Abstract: The invention is generally directed to methods and compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 and/or human TREM2. The methods provided herein find use in preventing, reducing risk, or treating an individual having dementia, frontotemporal dementia, Alzheimer's disease, Nasu-Hakola disease, or multiple sclerosis.

公开(公告)号：US20250144209A1

公开(公告)日：2025-05-08

申请号：US19014653

申请日：2025-01-09

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Seung-Joo Lee

IPC: A61K39/395 ,  A61P31/00 ,  A61P35/00 ,  C07K16/28

Abstract: The invention provides anti-SIRPA antibodies, methods of generating such antibodies, and therapeutic uses and methods employing the antibodies.

公开(公告)号：US12258410B2

公开(公告)日：2025-03-25

申请号：US18627754

申请日：2024-04-05

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Wei-Hsien Ho ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  C07K16/24 ,  C07K16/40 ,  C07K16/42 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a SIRPA polypeptide, e.g., a mammalian SIRPA or human SIRPA, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US12110327B2

公开(公告)日：2024-10-08

申请号：US17931757

申请日：2022-09-13

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Helen Lam ,  Francesca Avogadri-Connors ,  Seung-Joo Lee

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM1 protein, e.g., a mammalian TREM1 or human TREM1, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.