公开(公告)号：US3910891A

公开(公告)日：1975-10-07

申请号：US47713174

申请日：1974-06-06

Applicant: ALLIED CHEM

Inventor： BAKER JOSEFINA T ,  FUHRMANN ROBERT ,  KOFF FRED W ,  PISANCHYN JOHN

IPC: C07D207/22 ,  C07D211/76 ,  C07D223/12 ,  C07D207/14 ,  C07D211/56

CPC classification number: C07D223/12

Abstract: A process provided for separating an Alpha -amino- omega lactam of the formula:

WHEREIN N IS AN INTEGER FROM 0 TO 12, IN ITS FREE FORM FROM THE REARRANGED MIXTURE OBTAINED BY THE Beckmann rearrangement of an Alpha -aminocycloalkanone oxime of the formula:

WHEREIN N IS AN INTEGER FROM 0 TO 12, WHICH PROCESS COMPRISES THE STEPS OF: CONTACTING THE REARRANGED MIXTURE WITH A SOLVENT SELECTED FROM THE GROUP CONSISTING OF: A. LINEAR AND CYCLIC ETHERS AND POLYETHERS, B. C3 to C8 alcohols in the absence of chloride ions, C. NITRILES CONTAINING TWO OR MORE CARBON ATOMS, D. AROMATICS AND HALOAROMATICS IN THE PRESENCE OF AT LEAST ONE OF SAID (A) OR (B), WHEREIN THE HALO SUBSTITUENT IS CHLORINE OR BROMINE AND IS ATTACHED DIRECTLY TO THE RING, E. CHLOROFORM, F. TRICHLOROETHYLENE IN THE PRESENCE OF AT LEAST ONE OF SAID (A) OR (B), AND G. MIXTURES OF TWO OR MORE OF THE ABOVE, WHILE SIMULTANEOUSLY NEUTRALIZING THE RESULTANT SOLUTION WITH AN EXCESS OF ANHYDROUS AMMONIA BASED ON THE HYDROGEN ION CONCENTRATION IN THE SOLUTION, WHEREBY AN INSOLUBLE AMMONIUM SALT PRECIPITATE IS FORMED; AND SEPARATING A SOLUTION CONTAINING AN Alpha -AMINO- omega -LACTAM IN ITS FREE FORM FROM THE PRECIPITATE.

Abstract translation: 一种用于分离下式的α-氨基-ω-内酰胺的方法：

公开(公告)号：US3177189A

公开(公告)日：1965-04-06

申请号：US8519061

申请日：1961-01-27

Applicant: ALLIED CHEM

Inventor： ROBERT FUHRMANN ,  KOFF FRED W

IPC: C08F4/64 ,  C08F10/00

CPC classification number: C08F10/00 ,  C08F4/6495

公开(公告)号：US3917699A

公开(公告)日：1975-11-04

申请号：US42295273

申请日：1973-12-07

Applicant: ALLIED CHEM

Inventor： FUHRMANN ROBERT ,  KOFF FRED W ,  PISANCHYN JOHN

IPC: C07C251/44 ,  C07C20060101 ,  C07C131/04

CPC classification number: C07C249/08

Abstract: 2-Aminocycloalkanone oximes are produced by reacting, in an oxygen-free environment, hydroxylamine phosphate or hydroxylamine sulfate with anhydrous ammonia; removing the precipitated ammonium salt; adding ammonium chloride to the solution; maintaining the solution within a preselected temperature range while adding 2-chlorocycloalkanone; maintaining the desired temperature until the reaction is complete and isolating the oxime product.

Abstract translation: 通过在无氧环境下使磷酸羟胺或硫酸羟胺与无水氨反应制备2-氨基环烷酮肟; 除去沉淀的铵盐; 向溶液中加入氯化铵; 将溶液保持在预选的温度范围内，同时加入2-氯环烷酮; 保持所需的温度直到反应完成并分离出肟产物。

公开(公告)号：US3898213A

公开(公告)日：1975-08-05

申请号：US47713274

申请日：1974-06-06

Applicant: ALLIED CHEM

Inventor： KOFF FRED W

IPC: C07D223/12 ,  C07D53/06

CPC classification number: C07D223/12

Abstract: A process of separating an Alpha -amino- omega -lactam having the formula

WHEREIN N IS AN INTEGER FROM 0 TO 12, FROM MIXTURES CONTAINING THE SAME, WHICH PROCESS COMPRISES THE STEPS OF INTRODUCING CARBON DIOXIDE INTO A SOLUTION OF THE Alpha -AMINO- omega -LACTAM IN A SOLVENT SELECTED FROM THE GROUP CONSISTING OF ALIPHATIC KETONES CONTAINING 3 TO 9 CARBON ATOMS, C1 to C4 alkyl esters of C1 to C6 aliphatic carboxylic acids, linear and cyclic ethers and polyethers, chlorobenzene, toluene, chloroform, and mixtures thereof, to form a solid adduct; and separating the solid adduct from the solvent.

Abstract translation: 分离具有下式的α-氨基-ω-内酰胺的方法：其中N为0至12的整数，包含其的混合物，其过程包括将二氧化碳引入至α-OMINO-ω的溶液中的步骤 在由含有3至9个碳原子的烷基酮组成的组中选择的溶剂，C1至C6脂族羧酸的C1-C4烷基酯，直链和环醚和聚醚，氯苯，甲苯，氯仿及其混合物， 形成固体加合物; 并将固体加合物与溶剂分离。

公开(公告)号：US3297675A

公开(公告)日：1967-01-10

申请号：US33295263

申请日：1963-12-23

Applicant: ALLIED CHEM

Inventor： ROBERT FUHRMANN ,  MORRIS PLAINS ,  KOFF FRED W ,  DAVID JEROLAMON

IPC: C08F8/20

CPC classification number: C08F8/20 ,  C08F10/00

公开(公告)号：US3281449A

公开(公告)日：1966-10-25

申请号：US44788065

申请日：1965-04-13

Applicant: ALLIED CHEM

Inventor： DAVID JEROLAMON ,  MORRIS TOWNSHIP ,  KOFF FRED W ,  ROBERT FUHRMANN

CPC classification number: C07C255/00 ,  C07C253/14