公开(公告)号：US20180162856A1

公开(公告)日：2018-06-14

申请号：US15735235

申请日：2016-06-10

Applicant: ALMIRALL, S.A.

Inventor： Cristina ESTEVE TRIAS ,  Joan TALTAVULL MOLL ,  Jacob GONZALES RODRIGUEZ ,  Bernat VIDAL JUAN

IPC: C07D471/04 ,  C07D239/24

Abstract: New 2-(pyrazolopyridin-3-yl)pyrimidine derivatives are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy as inhibitors of Janus Kinases (JAK).

公开(公告)号：US20170158699A1

公开(公告)日：2017-06-08

申请号：US15313762

申请日：2015-05-21

Applicant: Almirall, S.A.

Inventor： Francesc CARRERA CARRERA ,  Juan Bautista PEREZ GARCIA ,  Bernat VIDAL JUAN ,  Francisco SANCHEZ IZQUIEROD ,  Maria Carme SERRA COMA

IPC: C07D487/04 ,  A61K31/53 ,  C07C309/30 ,  C07C309/04 ,  C07C309/35

CPC classification number: A61K31/53 ,  A61K31/573 ,  A61K45/06 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/30 ,  C07C309/35 ,  C07D487/04

Abstract: The present invention is directed to novel pharmaceutically acceptable, addition salts of (S)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile with sulfonic acid derivatives, in particular with methanesulfonic acid, naphthalene-2-sulfonic acid and para-toluenesulfonic acid, and pharmaceutically acceptable solvates thereof, and their use as Phosphoinositide 3-Kinase (PI3K) inhibitors.