公开(公告)号：US20180162856A1

公开(公告)日：2018-06-14

申请号：US15735235

申请日：2016-06-10

Applicant: ALMIRALL, S.A.

Inventor： Cristina ESTEVE TRIAS ,  Joan TALTAVULL MOLL ,  Jacob GONZALES RODRIGUEZ ,  Bernat VIDAL JUAN

IPC: C07D471/04 ,  C07D239/24

Abstract: New 2-(pyrazolopyridin-3-yl)pyrimidine derivatives are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy as inhibitors of Janus Kinases (JAK).

公开(公告)号：US20150118186A1

公开(公告)日：2015-04-30

申请号：US14589056

申请日：2015-01-05

Applicant: ALMIRALL, S.A.

Inventor： Jordi BACH TAÑA ,  Lluis Miquel PAGES SANTACANA ,  Joan TALTAVULL MOLL ,  Paul Robert EASTWOOD ,  Jacob GONZALEZ RODRIGUES ,  Victor GIULIO MATASSA

IPC: C07D487/04 ,  A61K31/506 ,  A61K45/06 ,  A61K31/4985 ,  A61K31/497 ,  C07D471/04 ,  A61K31/437

CPC classification number: C07D487/04 ,  A61K31/437 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/506 ,  A61K45/06 ,  C07D471/04

Abstract: New pyrazole derivatives having the chemical structure of formula (I) are disclosed; as well as process for theft preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

Abstract translation: 公开了具有式（I）化学结构的新的吡唑衍生物; 以及用于盗窃制备的方法，包含它们的药物组合物及其在治疗中作为Janus Kinases（JAK）抑制剂的用途。