公开(公告)号：US20230134563A1

公开(公告)日：2023-05-04

申请号：US18073347

申请日：2022-12-01

申请人： ALVIT LCS PHARMA LTD.

发明人： Yoram SELA ,  Itschak LAMENSDORF ,  Nachshol COHEN

IPC分类号： A61K31/352 ,  A61K31/05 ,  A61K45/06 ,  A61K47/32 ,  A61K47/38 ,  A61K47/36 ,  A61K47/34 ,  A61K9/00

摘要： The present invention provides a composition for a sublingual or a buccal delivery of cannabinoid active ingredients comprising a therapeutically effective dose of at least one cannabinoid, an emulsifying and penetration enhancing solubilizer such as vitamin E TPGS, Menthol as a permeation enhancer at 1-50 mg/dose, and polyethylene oxide as a mucoadhesive polymer at 2-100 mg, whereby the composition is administered sublingually or buccally in the form of tablet or film, and whereby the emulsifying and penetration enhancing solubilizer is present in an amount equal to or larger than 50% of the amount of the cannabinoid. The present invention further provides a composition for a sublingual or a buccal delivery of cannabinoid active ingredients comprising a therapeutically effective dose of at least one cannabinoid in a mucoadhesive dosage form, comprising sublingual tablets or films and having greater bioavailability than an alcohol-based oral spray having 5.2 mg/per spray of cannabinoid active ingredients.

公开(公告)号：US20200170994A1

公开(公告)日：2020-06-04

申请号：US16613194

申请日：2018-05-11

申请人： Yoram SELA ,  ALVIT LCS PHARMA LTD.

发明人： Yoram SELA ,  Itschak LAMENSDORF ,  Nachshol COHEN

IPC分类号： A61K31/352 ,  A61K47/38 ,  A61K31/125 ,  A61K9/00 ,  A61K47/36 ,  A61K31/485 ,  A61K31/4525 ,  A61K31/05 ,  A61K47/32 ,  A61K31/355 ,  A61K31/137

摘要： The present invention provides novel sublingual muco-adhesive cannabinoid compositions in the form of sublingual tablets or films, exhibiting improved bioavailability and stability, reduced side-effects such as irritation, and optionally lower dosage for the same therapeutic effect, in comparison with an alcohol-based oral spray having 5.2 mg of cannabinoid active ingredients per spray.