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公开(公告)号：US20210261637A1
公开(公告)日：2021-08-26
申请号：US17165351
申请日：2021-02-02
申请人： AMBRX, INC.
发明人： Thomas P. CUJEC , Roberto MARIANI , Anna-Maria A. HAYS PUTNAM , William M. KEEFE , Nick KNUDSEN , Lillian SKIDMORE , Jason PINKSTAFF , Vadim KRAYNOV
摘要： Modified FGF-21 polypeptides and uses thereof are provided.
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公开(公告)号：US20200031894A1
公开(公告)日：2020-01-30
申请号：US16443226
申请日：2019-06-17
申请人： AMBRX, INC.
发明人： Thomas P. CUJEC , Roberto MARIANI , Anna-Maria A. HAYS PUTNAM , William M. KEEFE , Nick KNUDSEN , Lillian SKIDMORE , Jason PINKSTAFF , Vadim KRAYNOV
摘要： Modified FGF-21 polypeptides and uses thereof are provided.
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公开(公告)号：US20190248863A1
公开(公告)日：2019-08-15
申请号：US16285986
申请日：2019-02-26
申请人： AMBRX, INC.
发明人： Vadim KRAYNOV , Nick KNUDSEN , Amha HEWET , Kristine DE DIOS , Jason PINKSTAFF , Lorraine SULLIIVAN
IPC分类号： C07K14/64
摘要： Modified relaxin polypeptides and their uses thereof are provided. Exemplary embodiments provide relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol. Additionally, use of said relaxin polypeptides for treatment of disease, such as heart failure, is also provided.
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公开(公告)号：US20240189392A1
公开(公告)日：2024-06-13
申请号：US18482487
申请日：2023-10-06
申请人： AMBRX, INC.
发明人： Vadim KRAYNOV , Nick KNUDSEN , Amha HEWET , Kristine DE DIOS , Jason PINKSTAFF , Lorraine SULLIVAN
CPC分类号： A61K38/2221 , C07K14/64
摘要： Modified relaxin polypeptides and their uses thereof are provided. Exemplary embodiments provide relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol. Additionally, use of said relaxin polypeptides for treatment of disease, such as heart failure, is also provided.
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公开(公告)号：US20190201491A1
公开(公告)日：2019-07-04
申请号：US16325345
申请日：2017-08-18
申请人： ELANCO US INC. , AMBRX, INC.
发明人： Peter Connor CANNING , Shailaja SRINAGESH , Anthony MANIBUSAN , Jason PINKSTAFF , Nickolas KNUDSEN
CPC分类号： A61K38/1825 , A61K38/00 , A61K38/18 , A61K47/10 , A61P3/00 , C07K14/503
摘要： The present application discloses PEG modified variants of a bFGF-21 polypeptide, compositions containing a bFGF-21 polypeptide variant, and methods useful in treating and/or preventing ketosis that administer the variant or a composition containing said bFGF-21 variant.
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公开(公告)号：US20220257720A1
公开(公告)日：2022-08-18
申请号：US17685658
申请日：2022-03-03
申请人： AMBRX, INC.
发明人： Vadim KRAYNOV , Nick KNUDSEN , Amha HEWET , Kristine DE DIOS , Jason PINKSTAFF , Lorraine SULLIVAN
摘要： Modified relaxin polypeptides and their uses thereof are provided. Exemplary embodiments provide relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol. Additionally, use of said relaxin polypeptides for treatment of disease, such as heart failure, is also provided.
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公开(公告)号：US20210277056A1
公开(公告)日：2021-09-09
申请号：US17142169
申请日：2021-01-05
申请人： Ambrx, Inc.
发明人： Zhenwei MIAO , Kyle ATKINSON , Sandra BIROC , Timothy BUSS , Melissa NEAL , Vadim KRAYNOV , Robin MARSDEN , Jason PINKSTAFF , Lillian SKIDMORE , Ying SUN , Agnieszka SZYDLIK , Delia Ianina LOPEZ DE VALENTA
IPC分类号： C07K5/103 , C07D207/08 , C07D401/12 , C07D417/12 , C07K5/02 , A61K47/68 , A61K38/07
摘要： Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.
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公开(公告)号：US20180298073A1
公开(公告)日：2018-10-18
申请号：US15953091
申请日：2018-04-13
申请人： AMBRX, INC.
发明人： Thomas P. CUJEC , Roberto MARIANI , Anna-Maria A. HAYS PUTNAM , William M. KEEFE , Nick KNUDSEN , Lillian SKIDMORE , Jason PINKSTAFF , Vadim KRAYNOV
CPC分类号： C07K14/50 , A61K38/00 , A61K38/1825 , A61K45/06 , A61K47/60 , C12N15/70 , Y02A50/473
摘要： Modified FGF-21 polypeptides and uses thereof are provided.
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公开(公告)号：US20220411469A1
公开(公告)日：2022-12-29
申请号：US17732285
申请日：2022-04-28
申请人： Ambrx, Inc.
发明人： Zhenwei MIAO , Kyle ATKINSON , Sandra BIROC , Timothy BUSS , Melissa NEAL , Vadim KRAYNOV , Robin MARSDEN , Jason PINKSTAFF , Lillian SKIDMORE , Ying SUN , Agnieszka SZYDLIK , Delia Ianina LOPEZ DE VALENTA
IPC分类号： C07K5/103 , C07D207/08 , C07D401/12 , C07D417/12 , C07K5/02 , A61K47/68 , A61K38/07
摘要： Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.
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公开(公告)号：US20180311368A1
公开(公告)日：2018-11-01
申请号：US15941033
申请日：2018-03-30
申请人： AMBRX, INC.
发明人： Vadim KRAYNOV , Nick KNUDSEN , Amha HEWET , Kristine DE DIOS , Jason PINKSTAFF , Lorraine SULLIVAN
摘要： Modified relaxin polypeptides and their uses thereof are provided
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