公开(公告)号：US3594413A

公开(公告)日：1971-07-20

申请号：US3594413D

申请日：1968-11-20

Applicant: AMERICAN HOME PROD

Inventor： ALBURN HARVEY E ,  FLETCHER HORACE

IPC: C07D235/02 ,  C07D499/00 ,  C07C101/14

CPC classification number: C07D235/02 ,  C07D499/00

Abstract: THIS INVENTION IS CONCERNED WITH THE PREPARATION OF CYCLOPENTENE - 1,1 - DICARBOXAMIDES; 1,3-DIAZASPIRO (4,4) NONENE-2,4 - DIONES; 1 - AMINOCYCLOPENTENE-1-CARBOXYLIC ACIDS; 1-(N - ALKYLAMINO) CYCLOPENTENE - 1 - CARBOXYLIC ACIDS; AND 3-OXA-1-AZASPIRO (4,4) NONENE-2,4-DIONES WHICH ARE INTERMEDIATE IN THE PREPARATION OF 6-(1-AMINOCYCLOPENTENE-1-CARBOXAMIDO) PENICILLANIC ACIDS WHICH ARE USEFUL ANTIBACTERIAL AGENTS.

公开(公告)号：US3532744A

公开(公告)日：1970-10-06

申请号：US3532744D

申请日：1967-07-28

Applicant: AMERICAN HOME PROD

Inventor： FLETCHER HORACE ,  RUSSELL PETER B ,  ALBURN HARVEY E

IPC: C07D235/02 ,  C07D263/52 ,  C07D499/00 ,  C07C101/04

CPC classification number: C07D235/02 ,  C07D263/52 ,  C07D499/00

公开(公告)号：US3564048A

公开(公告)日：1971-02-16

申请号：US3564048D

申请日：1968-06-25

Applicant: AMERICAN HOME PROD

Inventor： FLETCHER HORACE ,  ALBURN HARVEY E

IPC: C07C109/00

Abstract: ALICYCLIC ACIDS HAVING A HYDRAZINE SUBSTITUENT ARE PREPARED BY REACTING ACETYL HYDRAZINE WITH AN ALICYCLIC COMPOUND, THE CYCLOAKYLIDENE COMPOUND FORMED BEING THEN REACTED TO ADD A CYANO GROUP AND THE CYANO ALICYCLIC HYDRAZIDE FORMED IS THEN HYDROLYZED TO PRODUCE THE DESIRED COMPOUND. THE COMPOUNDS HAVE BIOCHEMICAL ACTIVITY.

公开(公告)号：US3704312A

公开(公告)日：1972-11-28

申请号：US3704312D

申请日：1970-10-30

Applicant: AMERICAN HOME PROD

Inventor： RUSSELL PETER B ,  FLETCHER HORACE ,  ALBURN HARVEY E

IPC: C07D235/24 ,  C07C101/04

CPC classification number: C07D235/24

Abstract: THE COMPOUNDS ARE BIALICYCLIC AMINO ACIDS WHICH ARE USEFUL AS ANTI-INFLAMMATORY AGENTS IN WARMBLOODED ANIMALS. THE COMPOUNDS ARE ALSO USEFUL, WHEN THEIR AMINO GROUPS ARE PROPERLY BLOCKED, FOR REACTING WITH 6-AMINOPENICILLANIC ACID, OR DERIVATIVES THEREOF, TO PREPARE PENICILLINS HAVING ANTIBIOTIC ACTIVITY, OR AS INTERMEDIATES IN THE PREPARATION OF THEIR CORRESPONDING N-CARBOXYANHYDRIDES WHICH MAY BE REACTED DIRECTLY WITH 6-AMINOPENICILLANIC ACID, OR DERIVATIVES THEREOF, TO PREPARE SAID PENICILLINS.