公开(公告)号：US3624101A

公开(公告)日：1971-11-30

申请号：US3624101D

申请日：1970-03-10

Applicant: AMERICAN HOME PROD

Inventor： SULKOWSKI THEODORE S ,  MASCITTI ALBERT A

IPC: C07D209/66 ,  C07D233/22 ,  C07D49/34

CPC classification number: C07D233/22 ,  C07D209/66

Abstract: 2,3-DIHYDRO-5-ARYL-5H-benz(f)imidazo(2,1-a)isoindol-5-ols have been prepared which are pharmacologically active as antidepressant.

公开(公告)号：US3539585A

公开(公告)日：1970-11-10

申请号：US3539585D

申请日：1968-10-03

Applicant: AMERICAN HOME PROD

Inventor： SULKOWSKI THEODORE S ,  MASCITTI ALBERT A

IPC: C07D277/14 ,  C07D277/30 ,  C07D91/24

CPC classification number: C07D277/30 ,  C07D277/14

公开(公告)号：US3445476A

公开(公告)日：1969-05-20

申请号：US3445476D

申请日：1967-03-14

Applicant: AMERICAN HOME PROD

Inventor： SULKOWSKI THEODORE S ,  MASCITTI ALBERT A

IPC: C07D209/46 ,  C07D27/08 ,  C07D31/42

CPC classification number: C07D209/46

公开(公告)号：US3649640A

公开(公告)日：1972-03-14

申请号：US3649640D

申请日：1970-03-10

Applicant: AMERICAN HOME PROD

Inventor： SULKOWSKI THEODORE S ,  MASCITTI ALBERT A

IPC: C07D233/22 ,  C07D233/64 ,  C07D49/34

CPC classification number: C07D233/22

Abstract: A-ARYL-3-(2-IMIDAZOLIN - 2-YL)-2-NAPTHALENEMETHANOLS HAVE BEEN PREPARED WHICH HAVE ANTI-INFLAMMATORY ACTIVITY.

公开(公告)号：US3558647A

公开(公告)日：1971-01-26

申请号：US3558647D

申请日：1969-03-03

Applicant: AMERICAN HOME PROD

Inventor： SULKOWSKI THEODORE S ,  MASCITTI ALBERT A

IPC: C07D209/44 ,  C07D209/46 ,  C07D27/50

CPC classification number: C07D209/46 ,  C07D209/44

Abstract: THE PRESENT INVENTION IS CONCERNED WITH 2-(2-AMINOPHENYL)PHTHALIMIDINES AND 2-(2-AMINOPHENYL)ISOINDOLINES. THESE 2-(2-AMINOPHENYL)PHTHALIMIDINES ARE USEFUL INTERMEDIATES IN THE PREPARATION OF THEIR CORRESPONDING 2-(2-AMINOPHENYL)ISOINDOLINES WHICH ARE PHARMACOLOGICALLY EFFICACIOUS AS ANTI-CONVULSANTS.

公开(公告)号：US3053831A

公开(公告)日：1962-09-11

申请号：US10794461

申请日：1961-05-05

Applicant: AMERICAN HOME PROD

Inventor： CHILDRESS SCOTT J ,  MASCITTI ALBERT A

IPC: C07D499/00 ,  C07D499/74

CPC classification number: C07D499/00

公开(公告)号：US3864360A

公开(公告)日：1975-02-04

申请号：US28063472

申请日：1972-08-14

Applicant: AMERICAN HOME PROD

Inventor： SULKOWSKI THEODORE S ,  MASCITTI ALBERT A

IPC: C07D209/48 ,  C07D233/22 ,  C07D27/50

CPC classification number: C07D233/22 ,  C07D209/48

Abstract: Novel compounds have been prepared which have useful pharmacological activity as well as intermediates for their production. Some of the processes have utility for the production of other pharmacologically active compounds. The active compounds of this invention are those of the following formulas:

WHEREIN R1 is selected from the group consisting of phenyl, monohalophenyl, dihalophenyl, mono(lower)alkylphenyl, di(lower)alkylphenyl, trifluoromethylphenyl, mono(lower)alkoxyphenyl, di(lower)alkoxyphenyl, thienyl, pyridyl, furyl, and tetrahydro-2-naphthyl; R2 is selected from the group consisting of hydrogen, halogen, amino, (lower)alkylamino, (lower)alkyl and (lower) alkoxy; R3 is hydrogen when R2 and R3 are dissimilar and when R2 and R3 are the same they are both selected from the group consisting of hydrogen, halogen, (lower)alkyl and (lower)alkoxy; R4 and R5 are lower alkyl and attached to the same carbon atom; X is the anion portion of a pharmacologically acceptable acid-addition salt.

Abstract translation: 已经制备了具有有用的药理活性的新型化合物以及用于其生产的中间体。 一些方法可用于生产其它药理活性化合物。 本发明的活性化合物是下式的那些：

公开(公告)号：US3624093A

公开(公告)日：1971-11-30

申请号：US3624093D

申请日：1970-03-10

Applicant: AMERICAN HOME PROD

Inventor： SULKOWSKI THEODORE S ,  MASCITTI ALBERT A

IPC: C07D471/04 ,  C07D35/10

CPC classification number: C07D471/04 ,  Y10S514/886

Abstract: Novel 5,6-disubstituted-2,3,5,6-tetrahydroimidazo-(2,1- Alpha )isoquinolin-6-ols have been prepared which are useful antiinflammatory agents.

公开(公告)号：US3466298A

公开(公告)日：1969-09-09

申请号：US3466298D

申请日：1967-03-14

Applicant: AMERICAN HOME PROD

Inventor： SULKOWSKI THEODORE S ,  MASCITTI ALBERT A

IPC: C07D209/44 ,  C07D209/46 ,  C07D209/48 ,  C07D27/48

CPC classification number: C07D209/48 ,  C07D209/44 ,  C07D209/46

公开(公告)号：US3647865A

公开(公告)日：1972-03-07

申请号：US3647865D

申请日：1968-04-16

Applicant: AMERICAN HOME PROD

Inventor： SULKOWSKI THEODORE S ,  MASCITTI ALBERT A

IPC: C07D333/24 ,  C07C101/42

CPC classification number: C07D333/24

Abstract: THIS INVENTION IS CONCERNED WITH TOLUIC ACIDS WHICH ARE USEFUL PRECURSORS IN THE PREPARATION OF 2-(AMINO(LOWER) ALKYL)PHTHALIMIDINES WHICH ARE UTILIZED AS INTERMEDIATES IN PREPARING 2-(AMINO(LOWER) ALKYL)ISOIDOLINES WHICH ARE PHARMACOLOGICALLY EFFICACIOUS AS ANTI-DEPRESSANTS AND ANOREXIANTS. THIS INVENTION IS ALSO CONCERNED WITH THE PROCESS OF PREPARING THESE TOLUIC ACID COMPOUNDS.