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    Process for the preparation of tetrahydropyrimidoisoindolols
    1.
    发明授权
    Process for the preparation of tetrahydropyrimidoisoindolols 失效
    四氢嘧啶异吲哚啉的制备方法

    公开(公告)号：US3898231A

    公开(公告)日：1975-08-05

    申请号：US39461573

    申请日：1973-09-05

    Applicant: AMERICAN HOME PROD

    Inventor： SULKOWSKI THEODORE S

    IPC: C07D209/48 ,  C07D209/50 ,  C07D239/06 ,  C07D487/14

    CPC classification number: C07D209/48 ,  C07D209/50

    Abstract: This invention is concerned with tetrahydropyrimidinyl phenyl carbonyl acid addition salts, imidazolinyl phenyl carbonyl acid addition salts, dihydroimidazoisoindolols, tetrahydropyrimidoisoindolols, and tetrahydropyrimidoisoindolol acid addition salts which are all pharmacologically efficacious as anti-depressants. The tetrahydropyrimidinyl phenyl carbonyl acid addition salts, the tetrahydropyrimidoisoindolols and the tetrahydropyrimidoisoindolol acid addition salts are also efficacious as diuretics while the imidazolinyl phenyl carbonyl acid addition salts and the dihydroimidazoisoindolols are efficacious as anorexiants. This invention is also concerned with several processes for the preparation of these compounds.

    Abstract translation: 本发明涉及四氢嘧啶基苯基羰基酸加成盐，咪唑啉基苯基羰基酸加成盐，二氢咪唑并吲哚洛尔，四氢嘧啶异吲哚洛尔和四氢嘧啶异吲哚洛酸加成盐，它们均作为抗抑郁药具有药理作用。 四氢嘧啶基苯基羰基酸加成盐，四氢嘧啶异吲哚洛尔和四氢嘧啶异吲哚洛酸加成盐也作为利尿剂是有效的，而咪唑啉基苯基羰基酸加成盐和二氢咪唑并吲哚洛尔作为厌食剂是有效的。 本发明还涉及制备这些化合物的几种方法。

    Method of producing anorexia using imidazolinyl phenyl carbonyl compounds, their acid addition salts and related compounds
    2.
    发明授权
    Method of producing anorexia using imidazolinyl phenyl carbonyl compounds, their acid addition salts and related compounds 失效
    使用咪唑啉基苯基羰基化合物，其酸加成盐和相关化合物产生厌食症的方法

    公开(公告)号：US3885037A

    公开(公告)日：1975-05-20

    申请号：US39495273

    申请日：1973-09-06

    Applicant: AMERICAN HOME PROD

    Inventor： SULKOWSKI THEODORE S

    IPC: C07D209/48 ,  C07D209/50 ,  A61K27/00

    CPC classification number: C07D209/48 ,  C07D209/50 ,  Y10S514/96

    Abstract: This invention is concerned with tetrahydropyrimidinyl phenyl carbonyl acid addition salts, imidazolinyl phenyl carbonyl acid addition salts, dihydroimidazoisoindolols, tetrahydropyrimidoisoindolols, and tetrahydropyrimidoisoindolol acid addition salts which are all pharmacologically efficacious as anti-depressants. The tetrahydropyrimidinyl phenyl carbonyl acid addition salts, the tetrahydropyrimidoisoindolols and the tetrahydropyrimidoisoindolol acid addition salts are also efficacious as diuretics while the imidazolinyl phenyl carbonyl acid addition salts and the dihydroimidazoisoindolols are efficacious as anorexiants. This invention is also concerned with several processes for the preparation of these compounds.

    Abstract translation: 本发明涉及四氢嘧啶基苯基羰基酸加成盐，咪唑啉基苯基羰基酸加成盐，二氢咪唑并吲哚洛尔，四氢嘧啶异吲哚洛尔和四氢嘧啶异吲哚洛酸加成盐，它们均作为抗抑郁药具有药理作用。 四氢嘧啶基苯基羰基酸加成盐，四氢嘧啶异吲哚洛尔和四氢嘧啶异吲哚洛酸加成盐也作为利尿剂是有效的，而咪唑啉基苯基羰基酸加成盐和二氢咪唑并吲哚洛尔作为厌食剂是有效的。 本发明还涉及制备这些化合物的几种方法。

    N-(2-{8 3-hydroxy-3-phenyl-2-phthalimidinyl{9 -ethyl)-sulfonamides
    7.
    发明授权
    N-(2-{8 3-hydroxy-3-phenyl-2-phthalimidinyl{9 -ethyl)-sulfonamides 失效
    N-（2- {8 3-羟基-3-苯基-2-邻苯二甲酰亚氨基{9-乙基） - 磺酰胺

    公开(公告)号：US3864360A

    公开(公告)日：1975-02-04

    申请号：US28063472

    申请日：1972-08-14

    Applicant: AMERICAN HOME PROD

    Inventor： SULKOWSKI THEODORE S ,  MASCITTI ALBERT A

    IPC: C07D209/48 ,  C07D233/22 ,  C07D27/50

    CPC classification number: C07D233/22 ,  C07D209/48

    Abstract: Novel compounds have been prepared which have useful pharmacological activity as well as intermediates for their production. Some of the processes have utility for the production of other pharmacologically active compounds. The active compounds of this invention are those of the following formulas:

    WHEREIN R1 is selected from the group consisting of phenyl, monohalophenyl, dihalophenyl, mono(lower)alkylphenyl, di(lower)alkylphenyl, trifluoromethylphenyl, mono(lower)alkoxyphenyl, di(lower)alkoxyphenyl, thienyl, pyridyl, furyl, and tetrahydro-2-naphthyl; R2 is selected from the group consisting of hydrogen, halogen, amino, (lower)alkylamino, (lower)alkyl and (lower) alkoxy; R3 is hydrogen when R2 and R3 are dissimilar and when R2 and R3 are the same they are both selected from the group consisting of hydrogen, halogen, (lower)alkyl and (lower)alkoxy; R4 and R5 are lower alkyl and attached to the same carbon atom; X is the anion portion of a pharmacologically acceptable acid-addition salt.

    Abstract translation: 已经制备了具有有用的药理活性的新型化合物以及用于其生产的中间体。 一些方法可用于生产其它药理活性化合物。 本发明的活性化合物是下式的那些：

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