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    (2-Pyrimidinylthio) alkanoic acids, esters, amides and hydrazides
    2.
    发明授权
    (2-Pyrimidinylthio) alkanoic acids, esters, amides and hydrazides 失效
    （2-嘧啶硫基）链烷酸，酯，酰胺和酰肼

    公开(公告)号：US3910910A

    公开(公告)日：1975-10-07

    申请号：US40935273

    申请日：1973-10-24

    申请人： AMERICAN HOME PROD

    发明人： SANTILLI ARTHUR A ,  SCOTESE ANTHONY C ,  TOMARELLI RUDOLPH M

    IPC分类号： C07D239/06 ,  C07D239/38 ,  C07D239/46 ,  C07D239/56 ,  C07D239/60 ,  C07D51/18

    CPC分类号： C07D239/06 ,  C07D239/38 ,  C07D239/47 ,  C07D239/56 ,  C07D239/60

    摘要： (2-Pyrimidinylthio)alkanoic acid, esters, amides and hydrazides as well as various 4- and 6-substituted derivatives thereof as depicted by the structural formula:

    in which R and R2 are independently -H or lower alkyl; R1 is -H, -halo or lower alkoxy; Z is -OH, OM, lower alkoxy or -(NH)p-NH2, wherein p is 0 to 1 and M is an alkali metal, alkaline earth metal or ammonium cation; Y is an aryl, amino or substituted amino radical; and M IS AN INTEGER FROM 0 TO 2, EXHIBIT ANTI-LIPEMIC ACTIVITY IN WARM-BLOODED ANIMALS.

    摘要翻译： （2-嘧啶硫基）链烷酸，酯，酰胺和酰肼以及其结构式如O | SCH（Ch2）mCZ | R所示的各种4-和6-取代的衍生物，其中R和R 2独立地为-H 或低级烷基; R1是-H， - 卤代或低级烷氧基; Z是-OH，OM，低级烷氧基或 - （NH）p-NH 2，其中p是0-1，M是碱金属，碱土金属或铵阳离子; Y是芳基，氨基或取代的氨基; 并且M是从0到2的整数，在温血动物中展示抗生素活性。