-
1.发明授权1,6-Bis(2-piperidinoethoxy)xanthene-9-one HCl, hydrate in the treatment of inflammation 失效1,6-双（2-哌啶子基乙氧基）呫吨-9-酮HCl，水合物治疗炎症
公开(公告)号：US3923991A
公开(公告)日：1975-12-02
申请号：US40699673
申请日：1973-10-16
申请人： AMERICAN HOME PROD
IPC分类号： C07D311/86 , A61K31/33 , A61K31/35 , A61K31/445
CPC分类号： C07D311/86
摘要： The disclosure is directed to bis(substituted alkyloxy)xanthen9-ones which have the formula
WHERE R1 and R2 are the same and are di(lower)alkylamino(lower)alkyl, piperidino(lower)alkyl, or hexamethyleneimino(lower)alkyl. The compounds have antiinflammatory and immunoregulant activity when evaluated in standard pharmacological procedures, and activity as interferon inducers.摘要翻译： 本发明涉及具有式WHERE R 1和R 2相同并且为二（低级）烷基氨基（低级）烷基，哌啶子基（低级）烷基或六亚甲基亚氨基（低级）烷基）的二（取代烷氧基）呫吨-9-酮 。 当在标准药理学过程中评估时，化合物具有抗炎和免疫调节活性，并且作为干扰素诱导剂的活性。
-
公开(公告)号：US3901887A
公开(公告)日：1975-08-26
申请号：US40934573
申请日：1973-10-24
申请人： AMERICAN HOME PROD
IPC分类号： C07D239/06 , C07D239/38 , C07D239/46 , C07D239/56 , C07D239/60 , C07D239/00
CPC分类号： C07D239/06 , C07D239/38 , C07D239/47 , C07D239/56 , C07D239/60
摘要： (2-Pyrimidinylthio)alkanoic acid, esters, amides and hydrazides as well as various 4- and 6-substituted derivatives thereof as depicted by the structural formula:
in which R and R2 are independently -H or lower alkyl; R1 is -H, -halo or lower alkoxy; Z is -OH, OM, lower alkoxy or -(NH)p-NH2, wherein p is 0 to 1 and M is an alkali metal, alkaline earth metal or ammonium cation; Y is an aryl, amino or substituted amino radical; and M IS AN INTEGER FROM 0 TO 2, EXHIBIT ANTI-LIPEMIC ACTIVITY IN WARM-BLOODED ANIMALS.-
3.发明授权(8-Substituted-9-oxoxanthen-3-yloxy) acetamidoximes and nitriles for their preparation 失效（8-取代-9-氧代蒽-3-基氧基）乙酰氨基肟和腈制备
公开(公告)号：US3923831A
公开(公告)日：1975-12-02
申请号：US46805174
申请日：1974-05-08
申请人： AMERICAN HOME PROD
IPC分类号： C07D311/86 , C07D311/84
CPC分类号： C07D311/86
摘要： The disclosure is directed to 6-substituted-1-alkyloxy-xanthen9-ones which have the formula
WHERE R1 is 2-acetamidoxime or acetonitrile and R2 is lower alkyl or hydrogen. The compounds have antitrichomonal activity or are intermediates in the preparation of trichomonicidal compounds.摘要翻译： 本公开涉及具有下式的6-取代-1-烷氧基呫吨-9-酮：其中R1是2-乙酰氨基肟或乙腈，R2是低级烷基或氢。 该化合物具有抗滴虫活性，或是制备杀微生物化合物的中间体。
-
4.发明授权
公开(公告)号：US3917650A
公开(公告)日：1975-11-04
申请号：US46805574
申请日：1974-05-08
申请人： AMERICAN HOME PROD
IPC分类号： C07D311/86 , C07D311/88
CPC分类号： C07D311/86
摘要： The disclosure is directed to ((9-oxoxanthene-2,6diyl)dioxy)diacetonitrile and diacetamidoxime which have the formula
WHERE R1 and R2 are the same and are acetonitrile or acetamidoxime. The compounds have trichomonacidal activity in vitro.摘要翻译： 本发明涉及具有式WHERE R1和R2相同并且是乙腈或乙酰胺肟的[（9-氧代呫吨-2,6-二基）二氧基]二乙腈和二乙酰胺肟。
-
5.发明授权1-Substituted -6-(2-hydroxy-3-substituted aminopropoxy)xanthen-9-ones 失效1-取代的-6-（2-羟基-3-取代的氨基丙氧基）呫吨-9-酮
公开(公告)号：US3912733A
公开(公告)日：1975-10-14
申请号：US46805374
申请日：1974-05-08
申请人： AMERICAN HOME PROD
IPC分类号： C07D311/86 , C07D295/00
CPC分类号： C07D311/86 , Y10S514/821
摘要： The disclosure is directed to 1-substituted-6-(2-hydroxy-3substituted aminopropoxy)xanthen-9-ones which have the formula
WHERE R1 is hydrogen or di(lower)alkylamino(lower)alkyl; and R2 and R3 when taken separately are hydrogen or lower alkyl and when taken together with the nitrogen atom to which they are attached are morpholino, piperazino, N-lower alkyl-piperazino, piperidino, lower alkylpiperidino and phen(lower)alkyl piperidino. The compounds exhibit antiarrhythmic activity when evaluated in standard pharmacological procedures or are intermediates in the preparation of compounds having antiarrhythmic activity. Also some of the compounds have anti inflammatory activity.摘要翻译： 本公开涉及具有式WHERE R 1为氢或二（低级）烷基氨基（低级）烷基的1-取代-6-（2-羟基-3-取代氨基丙氧基）呫吨-9-酮。 和R2和R3分别是氢或低级烷基，当与它们所连接的氮原子一起时，是吗啉代，哌嗪子基，N-低级烷基 - 哌嗪子基，哌啶子基，低级烷基哌啶子基和苯基（低级）哌啶子基。
-
公开(公告)号：US3910910A
公开(公告)日：1975-10-07
申请号：US40935273
申请日：1973-10-24
申请人： AMERICAN HOME PROD
IPC分类号： C07D239/06 , C07D239/38 , C07D239/46 , C07D239/56 , C07D239/60 , C07D51/18
CPC分类号： C07D239/06 , C07D239/38 , C07D239/47 , C07D239/56 , C07D239/60
摘要： (2-Pyrimidinylthio)alkanoic acid, esters, amides and hydrazides as well as various 4- and 6-substituted derivatives thereof as depicted by the structural formula:
in which R and R2 are independently -H or lower alkyl; R1 is -H, -halo or lower alkoxy; Z is -OH, OM, lower alkoxy or -(NH)p-NH2, wherein p is 0 to 1 and M is an alkali metal, alkaline earth metal or ammonium cation; Y is an aryl, amino or substituted amino radical; and M IS AN INTEGER FROM 0 TO 2, EXHIBIT ANTI-LIPEMIC ACTIVITY IN WARM-BLOODED ANIMALS.摘要翻译： （2-嘧啶硫基）链烷酸，酯，酰胺和酰肼以及其结构式如O | SCH（Ch2）mCZ | R所示的各种4-和6-取代的衍生物，其中R和R 2独立地为-H 或低级烷基; R1是-H， - 卤代或低级烷氧基; Z是-OH，OM，低级烷氧基或 - （NH）p-NH 2，其中p是0-1，M是碱金属，碱土金属或铵阳离子; Y是芳基，氨基或取代的氨基; 并且M是从0到2的整数，在温血动物中展示抗生素活性。
-
公开(公告)号：US3919211A
公开(公告)日：1975-11-11
申请号：US33139273
申请日：1973-02-12
申请人： AMERICAN HOME PROD
IPC分类号： C07D311/84 , C07D7/44 , C07D29/34 , C07D87/46
CPC分类号： C07D311/84 , Y10S514/889
摘要： WHERE R1 is hydrogen or lower alkyl; R2 is lower alkoxy(lower)alkyl, di(lower)alkylamino (lower)alkyl, halobenzyl or morpholino(lower)alkyl; and R1 and R2 taken together with the nitrogen of the sulfonamide group are piperidino, piperazino, phenylpiperazino and morpholino. The compounds have activity as central nervous system depressants.
The disclosure is directed to 9-oxoxanthene-N,N''bis(substituted)-2,7-disulfonamides which have the formula摘要翻译： 本发明涉及9-氧代呫吨-N，N'-双（取代的）-2,7-二磺酰胺，其具有下式：其中R 1是氢或低级烷基; R2是低级烷氧基（低级）烷基，二（低级）烷基氨基（低级）烷基，卤代苄基或吗啉代（低级）烷基; 并且R 1和R 2与磺酰胺基团的氮一起是哌啶子基，哌嗪基，苯基哌嗪基和吗啉代。
-
8.发明授权{8 (9-Oxoxanthene-2,6-diyl)dioxy{9 diacetic acid, diethyl ester, dihydrazides and derivatives thereof 失效{8（9-氧氧杂蒽-2,6-二基）二氧基{二乙酸二乙酯，二酰肼及其衍生物
公开(公告)号：US3917586A
公开(公告)日：1975-11-04
申请号：US46805474
申请日：1974-05-08
申请人： AMERICAN HOME PROD
IPC分类号： C07D311/86
CPC分类号： C07D311/86
摘要： The disclosure is directed to ((9-oxoxanthene-2,6diyl)dioxy)diacetic acid, diethyl ester, dihydrazides and derivatives thereof which have the formula
WHERE R1 and R2 are the same and are selected from the class consisting of lower alkyloxy, hydrazino and nitrofurfurylidene hydrazino. The compounds exhibit antiamebic activity when evaluated in standard pharmacological procedures.摘要翻译： 本发明涉及[（9-氧代呫吨-2,6-二基）二氧基]二乙酸，二乙酯，二酰肼及其衍生物，其具有下式，其中R 1和R 2相同，并且选自由低级烷氧基 ，肼基和硝基糠基肼。
-
9.发明授权(2-pyrimidinylthio) alkanoic acids, esters, amides and hydrazides 失效（2-PYRIMIDINYLTHIO）碱性酸，酯，氨基和水合物
公开(公告)号：US3896129A
公开(公告)日：1975-07-22
申请号：US40935373
申请日：1973-10-24
申请人： AMERICAN HOME PROD
IPC分类号： C07D239/06 , C07D239/38 , C07D239/46 , C07D239/56 , C07D239/60 , C07D51/40
CPC分类号： C07D239/06 , C07D239/38 , C07D239/47 , C07D239/56 , C07D239/60
摘要： (2-Pyrimidinylthio)alkanoic acid, esters, amides and hydrazides as well as various 4- and 6-substituted derivatives thereof as depicted by the structural formula:
IN WHICH R and R2 are independently -H of lower alkyl, R1 is H, -halo or lower alkoxy; Z is -OH, OM, lower alkoxy or -(NH)pNH2, wherein p is 0 to 1 and M is an alkali metal, alkaline earth metal or ammonium cation; Y is an aryl, amino or substituted amino radical; and m is an integer from 0 to 2, exhibit antilipemic activity in warm-blooded animals.-
10.发明授权(2-pyrimidinylthio)alkanoic acids, esters, amides and hydrazides, as anti-lipemic agents 失效（2-PYRIMIDINYLTHIO）ALKANOIC ACIDS，ESTERS，AMIDES AND HYDRAZIDES，ANTI-LICEMIC AGENTS
公开(公告)号：US3876789A
公开(公告)日：1975-04-08
申请号：US40911573
申请日：1973-10-24
申请人： AMERICAN HOME PROD
IPC分类号： C07D239/06 , C07D239/38 , C07D239/46 , C07D239/56 , C07D239/60 , A61K27/00
CPC分类号： C07D239/06 , C07D239/38 , C07D239/47 , C07D239/56 , C07D239/60
摘要： (2-Pyrimidinylthio)alkanoic acid, esters, amides and hydrazides as well as various 4- and 6-substituted derivatives thereof as depicted by the structural formula
In which
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.01 秒)
