公开(公告)号：US20170182016A1

公开(公告)日：2017-06-29

申请号：US15300690

申请日：2015-04-03

Applicant: AMGEN, INC.

Inventor： Sean CAENEPEEL ,  Angela COXON ,  Zhiqiang DU ,  Paul HUGHES ,  Robert LOBERG ,  Gift NGARMCHAMNANRITH ,  Beate SABLE

IPC: A61K31/4375 ,  C12Q1/68

CPC classification number: A61K31/4375 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158

Abstract: The present invention relates to methods of therapeutic treatment of cancer using selective tyrosine kinase inhibitors and cancer biomarkers, such as MET amplification and high Met expression for patient selection.

公开(公告)号：US20140154243A1

公开(公告)日：2014-06-05

申请号：US14086864

申请日：2013-11-21

Applicant: AMGEN FREMONT INC. ,  AMGEN INC.

Inventor： Teresa L BURGESS ,  Angela COXON ,  Larry L GREEN ,  Ke ZHANG

IPC: C07K16/22 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Specific binding agents that interact with hepatocyte growth factor (HGF) are described. Methods of treating cancer by administering a pharmaceutically effective amount of a specific binding agent to HGF are described. Methods of detecting the amount of HGF in a sample using a specific binding agent to HGF are described.

Abstract translation: 描述了与肝细胞生长因子（HGF）相互作用的特异性结合剂。 描述了通过向HGF施用药学有效量的特异性结合剂来治疗癌症的方法。 描述了使用特异性结合剂向HGF检测样品中HGF的量的方法。