公开(公告)号：US20170182016A1

公开(公告)日：2017-06-29

申请号：US15300690

申请日：2015-04-03

Applicant: AMGEN, INC.

Inventor： Sean CAENEPEEL ,  Angela COXON ,  Zhiqiang DU ,  Paul HUGHES ,  Robert LOBERG ,  Gift NGARMCHAMNANRITH ,  Beate SABLE

IPC: A61K31/4375 ,  C12Q1/68

CPC classification number: A61K31/4375 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158

Abstract: The present invention relates to methods of therapeutic treatment of cancer using selective tyrosine kinase inhibitors and cancer biomarkers, such as MET amplification and high Met expression for patient selection.