公开(公告)号：US20210047407A1

公开(公告)日：2021-02-18

申请号：US16964452

申请日：2019-02-08

申请人： AMGEN INC.

发明人： Twinkle R. Christian ,  Daxian Shan

IPC分类号： C07K16/28 ,  A61K47/61 ,  A61K47/60 ,  A61K47/54

摘要： The present disclosure describes low pH formulations comprising, e.g., an antigen-binding protein that binds CD3, at least one buffer agent, at least one saccharide and at least one surfactant.

公开(公告)号：US20240336685A1

公开(公告)日：2024-10-10

申请号：US17281896

申请日：2019-09-27

申请人： AMGEN INC.

发明人： Bharadwaj Jagannathan ,  Joon Huh ,  Michael J. Treuheit ,  Daxian Shan

IPC分类号： C07K16/28

CPC分类号： C07K16/2809 ,  C07K16/2803 ,  C07K16/2878 ,  C07K2317/10 ,  C07K2317/31

摘要： The invention disclosed herein relates to methods for reducing aggregation of bispecific antibodies, for example reducing aggregation of bispecific T cell engager (BiTE) antibody constructs, resulting from storage under frozen conditions by holding the antibodies at certain temperatures after thaw.