公开(公告)号：US20240336685A1

公开(公告)日：2024-10-10

申请号：US17281896

申请日：2019-09-27

Applicant: AMGEN INC.

Inventor： Bharadwaj Jagannathan ,  Joon Huh ,  Michael J. Treuheit ,  Daxian Shan

IPC: C07K16/28

CPC classification number: C07K16/2809 ,  C07K16/2803 ,  C07K16/2878 ,  C07K2317/10 ,  C07K2317/31

Abstract: The invention disclosed herein relates to methods for reducing aggregation of bispecific antibodies, for example reducing aggregation of bispecific T cell engager (BiTE) antibody constructs, resulting from storage under frozen conditions by holding the antibodies at certain temperatures after thaw.

公开(公告)号：US20230310324A1

公开(公告)日：2023-10-05

申请号：US18024893

申请日：2021-09-14

Applicant: AMGEN INC.

Inventor： Arnold McAuley ,  Michael J. Treuheit ,  Twinkle R. Christian ,  Bharadwaj Jagannathan

IPC: A61K9/19 ,  A61K47/26 ,  A61K47/18 ,  C07K16/28

CPC classification number: A61K9/19 ,  A61K47/26 ,  A61K47/183 ,  C07K16/2863 ,  C07K2317/31

Abstract: Disclosed herein are methods of preparing lyophilized formulations comprising a protein, such as an antibody or a bispecific antibody construct, that exhibits improved storage stability.

公开(公告)号：US20220378908A1

公开(公告)日：2022-12-01

申请号：US17771313

申请日：2020-10-23

Applicant: AMGEN INC.

Inventor： Chen Zhu ,  Daniel Gerard Greene ,  Qi Hao ,  Sekhar Kanapuram ,  Michael J. Treuheit

IPC: A61K39/395 ,  A61K47/26 ,  A61K47/10 ,  A61J1/14 ,  A61J1/10

Abstract: The present invention relates to compositions and methods for minimizing protein loss (e.g., due to adsorption to solid surfaces) at low protein concentrations. Inventions disclosed herein generally relate to the field of compositions comprising proteins, in particular, pharmaceutical compositions comprising therapeutic proteins at low protein concentrations. Inventions disclosed herein also relate to methods of administering the composition to a subject in need thereof.