公开(公告)号：US20230020514A1

公开(公告)日：2023-01-19

申请号：US17902168

申请日：2022-09-02

Applicant: AMGEN INC.

Inventor： Hong SUN ,  Eduardo DUNAYEVICH ,  Robert A. LENZ ,  Gabriel VARGAS

IPC: C07K16/28

Abstract: The present invention relates to methods of migraine prophylaxis using anti-CGRP receptor antibodies or binding fragments. In particular, methods for preventing or reducing the occurrence of migraine headache in a patient in need thereof comprising administering to the patient an anti-CGRP receptor or binding fragment according to specific dosage regimens are disclosed. Pharmaceutical compositions and administration devices comprising anti-CGRP receptor antibodies or binding fragments for use in the methods are also described.

公开(公告)号：US20160311913A1

公开(公告)日：2016-10-27

申请号：US15136736

申请日：2016-04-22

Applicant: AMGEN INC.

Inventor： Hong SUN ,  Eduardo DUNAYEVICH ,  Robert A. LENZ ,  Gabriel VARGAS

IPC: C07K16/28

CPC classification number: C07K16/2869 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/76

Abstract: The present invention relates to methods of migraine prophylaxis using anti-CGRP receptor antibodies or binding fragments. In particular, methods for preventing or reducing the occurrence of migraine headache in a patient in need thereof comprising administering to the patient an anti-CGRP receptor or binding fragment according to specific dosage regimens are disclosed. Pharmaceutical compositions and administration devices comprising anti-CGRP receptor antibodies or binding fragments for use in the methods are also described.

Abstract translation: 本发明涉及使用抗CGRP受体抗体或结合片段的偏头痛预防方法。 特别地，公开了在有需要的患者中预防或减少偏头痛的发生的方法，其包括根据特定剂量方案向患者施用抗CGRP受体或结合片段。 还描述了包含抗CGRP受体抗体或用于该方法的结合片段的药物组合物和给药装置。