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公开(公告)号：US20230020514A1
公开(公告)日：2023-01-19
申请号：US17902168
申请日：2022-09-02
Applicant: AMGEN INC.
Inventor： Hong SUN , Eduardo DUNAYEVICH , Robert A. LENZ , Gabriel VARGAS
IPC: C07K16/28
Abstract: The present invention relates to methods of migraine prophylaxis using anti-CGRP receptor antibodies or binding fragments. In particular, methods for preventing or reducing the occurrence of migraine headache in a patient in need thereof comprising administering to the patient an anti-CGRP receptor or binding fragment according to specific dosage regimens are disclosed. Pharmaceutical compositions and administration devices comprising anti-CGRP receptor antibodies or binding fragments for use in the methods are also described.
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公开(公告)号：US20160311913A1
公开(公告)日：2016-10-27
申请号：US15136736
申请日：2016-04-22
Applicant: AMGEN INC.
Inventor： Hong SUN , Eduardo DUNAYEVICH , Robert A. LENZ , Gabriel VARGAS
IPC: C07K16/28
CPC classification number: C07K16/2869 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/76
Abstract: The present invention relates to methods of migraine prophylaxis using anti-CGRP receptor antibodies or binding fragments. In particular, methods for preventing or reducing the occurrence of migraine headache in a patient in need thereof comprising administering to the patient an anti-CGRP receptor or binding fragment according to specific dosage regimens are disclosed. Pharmaceutical compositions and administration devices comprising anti-CGRP receptor antibodies or binding fragments for use in the methods are also described.
Abstract translation: 本发明涉及使用抗CGRP受体抗体或结合片段的偏头痛预防方法。 特别地，公开了在有需要的患者中预防或减少偏头痛的发生的方法，其包括根据特定剂量方案向患者施用抗CGRP受体或结合片段。 还描述了包含抗CGRP受体抗体或用于该方法的结合片段的药物组合物和给药装置。
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公开(公告)号：US20210095016A1
公开(公告)日：2021-04-01
申请号：US17031674
申请日：2020-09-24
Applicant: AMGEN INC.
Inventor： Agnes E. HAMBURGER , Cen XU , Hong SUN , Yuan D. SHIH , Dohan WEERARATNE
Abstract: The present invention relates to monoclonal antibodies that specifically bind to human pituitary adenylate cyclase activating polypeptide (PACAP) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the monoclonal antibodies are also described.
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公开(公告)号：US20180362643A1
公开(公告)日：2018-12-20
申请号：US16063152
申请日：2016-12-15
Applicant: AMGEN INC.
Inventor： Agnes E. HAMBURGER , Cen XU , Hong SUN , Yuan D. SHIH , Dohan WEERARATNE
CPC classification number: C07K16/26 , A61K9/0019 , A61K2039/505 , A61P25/06 , C07K16/4283 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76
Abstract: The present invention relates to monoclonal antibodies that specifically bind to human pituitary adenylate cyclase activating polypeptide (PACAP) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the monoclonal antibodies are also described.
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