公开(公告)号：US20240182558A1

公开(公告)日：2024-06-06

申请号：US18287597

申请日：2022-04-22

Applicant: AMGEN INC.

Inventor： Pavel Bondarenko ,  Liuqing Shi ,  Hao Zhang

IPC: C07K16/24 ,  A61K39/00 ,  C12N15/63

CPC classification number: C07K16/246 ,  C12N15/63 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present application relates, in general, to compositions or variants of anti-TSLP antibody tezepelumab having increased stability compared to tezepelumab when stored over long periods of time.

公开(公告)号：US20240190951A1

公开(公告)日：2024-06-13

申请号：US18287593

申请日：2022-04-22

Applicant: AMGEN INC.

Inventor： Hao Zhang ,  Alla Polozova ,  Kelly Fitzpatrick ,  Kristin Abrams ,  Dong Xiang ,  Marisa K. Joubert

IPC: C07K16/24 ,  A61K39/00 ,  G01N33/68

CPC classification number: C07K16/244 ,  G01N33/6845 ,  G01N33/6854 ,  A61K39/00 ,  C07K2317/21 ,  C07K2317/41 ,  G01N2500/10

Abstract: The present application relates, in general, to compositions comprising anti-TSLP antibody tezepelumab and derivatives thereof having antibody quality attributes.