公开(公告)号：US09346798B2

公开(公告)日：2016-05-24

申请号：US14377478

申请日：2013-02-12

Applicant: AMGEN INC.

Inventor： Christiane Boezio ,  Alessandro Boezio ,  Howard Bregman ,  Nagasree Chakka ,  James R. Coats ,  Katrina Woodin Copeland ,  Erin F. Dimauro ,  Thomas Dineen ,  Hua Gao ,  Daniel La ,  Isaac E. Marx ,  Hanh Nho Nguyen ,  Emily Anne Peterson ,  Matthew Weiss

IPC: C07D413/12 ,  C07D417/12 ,  C07D413/14 ,  C07D471/04 ,  C07D417/14

CPC classification number: C07D417/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其是电压门控钠通道的抑制剂，特别是Nav 1.7。 该化合物可用于治疗可通过抑制钠通道（例如疼痛障碍）治疗的疾病。 还提供含有本发明化合物的药物组合物。

公开(公告)号：US20150057271A1

公开(公告)日：2015-02-26

申请号：US14377478

申请日：2013-02-12

Applicant: AMGEN INC.

Inventor： Christiane Boezio ,  Alessandro Boezio ,  Howard Bregman ,  Nagasree Chakka ,  James R. Coats ,  Katrina Woodin Copeland ,  Erin F. Dimauro ,  Thomas Dineen ,  Hua Gao ,  Daniel La ,  Isaac E. Marx ,  Hanh Nho Nguyen ,  Emily Anne Peterson ,  Matthew Weiss

IPC: C07D417/14 ,  C07D471/04 ,  C07D413/14 ,  C07D417/12 ,  C07D413/12

CPC classification number: C07D417/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其是电压门控钠通道的抑制剂，特别是Nav 1.7。 该化合物可用于治疗可通过抑制钠通道（例如疼痛障碍）治疗的疾病。 还提供含有本发明化合物的药物组合物。

公开(公告)号：US09663508B2

公开(公告)日：2017-05-30

申请号：US15026740

申请日：2014-10-01

Applicant: AMGEN INC.

Inventor： Howard Bregman ,  Nagasree Chakka ,  Erin F. Dimauro ,  Hua Gao ,  Hakan Gunaydin ,  Hongbing Huang ,  Philip R. Olivieri ,  Laurie Schenkel ,  Matthew Weiss

IPC: C07D417/12 ,  C07D213/64 ,  C07D213/26 ,  C07D213/643 ,  C07D213/70 ,  C07D401/04 ,  C07D405/12

CPC classification number: C07D417/12 ,  C07D213/26 ,  C07D213/64 ,  C07D213/643 ,  C07D213/70 ,  C07D401/04 ,  C07D405/12

Abstract: The present invention provides compounds of Formula (Ia), and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of voltage-gated sodium channels, in particular Nav 1.7. as described in the specification. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention, as well as intermediates and processes useful for making the compounds.