专利检索 ap:("AMGEN INC.") AND inv:"JERRY RYAN HOLDER" 第 1 页

1.

发明公开
METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING ANTAGONISTIC BINDING PROTEINS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR)/GLP-1 RECEPTOR AGONIST FUSION PROTEINS 审中-公开

公开(公告)号：US20240261421A1

公开(公告)日：2024-08-08

申请号：US18614508

申请日：2024-03-22

申请人： AMGEN INC.

发明人： KENNETH W. WALKER , JERRY RYAN HOLDER , DAVID J. LLOYD , SHU-CHEN LU , MURIELLE M. VENIANT-ELLISON , SHANAKA STANISLAUS

IPC分类号： A61K47/65 , C07K14/72 , C07K16/26

CPC分类号： A61K47/65 , C07K14/72 , C07K16/26 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/94 , C07K2319/30

摘要： Methods of treating metabolic diseases and disorders using a composition comprising a GLP-1/GIPR antigen binding protein fusion protein are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises the C-terminus of a GLP-1 analog fused to the N-terminus of the light chain variable or heavy chain variable region of an antibody or functional fragment thereof that binds GIPR, optionally with a linker in between.