公开(公告)号：US20190270817A1

公开(公告)日：2019-09-05

申请号：US16245733

申请日：2019-01-11

Applicant: AMGEN INC.

Inventor： Khaled M.K.Z. Ali ,  Neeraj Jagdish Agrawal ,  Gunasekaran Kannan ,  Ian Foltz ,  Zhulun Wang ,  Daren Bates ,  Marissa Mock ,  Shunsuke Takenaka

IPC: C07K16/28 ,  C07K16/06 ,  A61P35/00 ,  C12N15/85

Abstract: Provided herein are PD-1 antigen-binding proteins and related nucleic acids, vectors, host cells, kits and pharmaceutical compositions. Methods of making PD-1 antigen-binding proteins and methods of treating a subject are further provided.

公开(公告)号：US20190046611A1

公开(公告)日：2019-02-14

申请号：US16054035

申请日：2018-08-03

Applicant: AMGEN INC.

Inventor： Khaled M.K.Z. Ali ,  Neeraj Jagdish Agrawal ,  Gunasekaran Kannan ,  Ian Foltz ,  Zhulun Wang ,  Darren Bates ,  Marissa Mock ,  Shunsuke Takenaka

IPC: A61K38/20 ,  A61P35/00 ,  C12N15/63 ,  C07K16/28

Abstract: Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.