公开(公告)号：US12139702B2

公开(公告)日：2024-11-12

申请号：US17957982

申请日：2022-09-30

Applicant: AMGEN INC.

Inventor： Chuck Z. Li ,  Brandon Zachary Sarich ,  Phillip Ng

IPC: C12M3/00 ,  C12M1/32 ,  C12M1/42 ,  C12N5/00 ,  C12N5/077 ,  C12N13/00 ,  G01N33/50

Abstract: A well for electrically stimulating at least one cell. The well includes a bottom portion and comprises an adaptive electrode arrangement for introducing an electric field into the well. The adaptive electrode arrangement includes a pair of electrodes disposed within the well. Each electrode of the pair of electrodes has a distal end and is independently and axially displaceable relative to the other electrode and the bottom portion of the well. The distal end of each electrode of the pair of electrodes is in contact with the bottom portion of the well, ensuring a uniform and constant electric field is applied within the well.

公开(公告)号：US20230022041A1

公开(公告)日：2023-01-26

申请号：US17957982

申请日：2022-09-30

Applicant: AMGEN INC.

Inventor： Chuck Z. Li ,  Brandon Zachary Sarich ,  Phillip Ng

IPC: C12N13/00 ,  C12M1/32 ,  C12M1/42 ,  C12N5/077 ,  G01N33/50

Abstract: A well for electrically stimulating at least one cell. The well includes a bottom portion and comprises an adaptive electrode arrangement for introducing an electric field into the well. The adaptive electrode arrangement includes a pair of electrodes disposed within the well. Each electrode of the pair of electrodes has a distal end and is independently and axially displaceable relative to the other electrode and the bottom portion of the well. The distal end of each electrode of the pair of electrodes is in contact with the bottom portion of the well, ensuring a uniform and constant electric field is applied within the well.

公开(公告)号：US11492609B2

公开(公告)日：2022-11-08

申请号：US16639016

申请日：2018-08-07

Applicant: AMGEN INC.

Inventor： Chuck Z. Li ,  Brandon Zachary Sarich ,  Phillip Ng

IPC: C12M3/00 ,  C12N5/00 ,  C12N13/00 ,  C12M1/32 ,  C12M1/42 ,  C12N5/077 ,  G01N33/50

Abstract: A well for electrically stimulating at least one cell. The well includes a bottom portion and comprises an adaptive electrode arrangement for introducing an electric field into the well. The adaptive electrode arrangement includes a pair of electrodes disposed within the well. Each electrode of the pair of electrodes has a distal end and is independently and axially displaceable relative to the other electrode and the bottom portion of the well. The distal end of each electrode of the pair of electrodes is in contact with the bottom portion of the well, ensuring a uniform and constant electric field is applied within the well.

公开(公告)号：US20200224188A1

公开(公告)日：2020-07-16

申请号：US16639016

申请日：2018-08-07

Applicant: AMGEN INC.

Inventor： Chuck Z. Li ,  Brandon Zachary Sarich ,  Phillip Ng

IPC: C12N13/00 ,  C12M1/32 ,  C12M1/42 ,  C12N5/077 ,  G01N33/50

Abstract: A well for electrically stimulating at least one cell. The well includes a bottom portion and comprises an adaptive electrode arrangement for introducing an electric field into the well. The adaptive electrode arrangement includes a pair of electrodes disposed within the well. Each electrode of the pair of electrodes has a distal end and is independently and axially displaceable relative to the other electrode and the bottom portion of the well. The distal end of each electrode of the pair of electrodes is in contact with the bottom portion of the well, ensuring a uniform and constant electric field is applied within the well.