公开(公告)号：US20230295267A1

公开(公告)日：2023-09-21

申请号：US18206963

申请日：2023-06-07

Applicant: AMGEN INC.

Inventor： Jeonghoon SUN ,  Lei-Ting Tony TAM ,  Mark Leo MICHAELS ,  Thomas Charles BOONE ,  Rohini R. DESHPANDE ,  Yue-Sheng LI ,  Huiquan HAN

IPC: C07K14/71 ,  C07K14/495

CPC classification number: C07K14/71 ,  C07K14/495 ,  A61K38/00

Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.