公开(公告)号：US20230265145A1

公开(公告)日：2023-08-24

申请号：US18001913

申请日：2021-06-25

Applicant: AMGEN INC.

Inventor： Hailing HSU ,  Ian FOLTZ ,  Marissa MOCK ,  Victor Mitch LUNA ,  Ming ZHANG ,  Sharon Lynn WANNBERG ,  Gamze Ozlem CAMDERE TAPIA ,  Timothy Patrick RILEY

IPC: C07K14/54 ,  C07K16/28

CPC classification number: C07K14/5428 ,  C07K16/2803 ,  A61K38/00 ,  C07K2319/00

Abstract: Abstract: The present disclosure relates, in general, to muteins of IL-10 that are stable as monomers, antigen binding proteins that bind to TREM-1, and antigen binding proteins comprising IL-10 muteins and antigen binding moieties, e.g., anti-TREM-1 antibodies, and compositions thereof. The disclosure also provides methods of treating inflammatory disease, such as inflammatory bowel disease or ulcerative colitis, using the compositions.