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公开(公告)号：US20240344025A1
公开(公告)日：2024-10-17
申请号：US18294854
申请日：2022-09-21
发明人： Wendell A. LIM , Nishith REDDY , Milos SIMIC
IPC分类号： C12N5/0783 , A61K35/17 , A61P37/06 , C07K14/54 , C07K14/55 , C07K14/705 , C07K16/24
CPC分类号： C12N5/0636 , A61K35/17 , A61P37/06 , C07K14/5428 , C07K14/55 , C07K14/70596 , C07K16/24 , C12N2510/00
摘要： Provided herein is a synthetic immuno-suppressive cell that contains comprises a molecular circuit comprising the following components: (a) a binding-triggered transcriptional switch (BTTS); and one or both of: (b) a nucleic acid encoding a pro-inflammatory cytokine sink, (c) a nucleic acid encoding an anti-inflammatory cytokine, (d) a nucleic acid encoding an immune inhibitory receptor, or ligand thereof, and (c) a nucleic acid encoding an ectonucleotidase. In this circuit, binding of the BTTS to a marker on the surface of a target cell activates expression of one or any combination of (b)-(c) by the synthetic immuno-suppressive cell.
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公开(公告)号：US12116391B2
公开(公告)日：2024-10-15
申请号：US18501856
申请日：2023-11-03
发明人： John Mumm
IPC分类号： C07K14/54 , A61K38/00 , A61K39/395 , A61P35/00 , A61P37/06 , C07K14/55 , C07K16/10 , C07K16/28 , C07K16/32 , C07K16/46 , A61K39/00
CPC分类号： C07K14/5428 , A61P35/00 , A61P37/06 , C07K14/5406 , C07K14/55 , C07K16/10 , C07K16/1045 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K16/464 , A61K38/00 , A61K2039/505 , A61K2039/545 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/30
摘要： The application relates to a dual cytokine fusion protein composition, pharmaceutical composition, and/or formulation thereof comprising IL-10 or IL-10 variant molecules fused to a single chain variable fragment scaffolding system and a second cytokine, where the second cytokine is linked in the hinge region of the scFv. The application also relates to methods of using the dual cytokine fusion protein composition for treating cancer, inflammatory diseases or disorders, and immune and immune mediated diseases or disorders.
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公开(公告)号：US12116390B2
公开(公告)日：2024-10-15
申请号：US18501850
申请日：2023-11-03
发明人： John Mumm
IPC分类号： C07K14/54 , A61K38/00 , A61K39/395 , A61P35/00 , A61P37/06 , C07K14/55 , C07K16/10 , C07K16/28 , C07K16/32 , C07K16/46 , A61K39/00
CPC分类号： C07K14/5428 , A61P35/00 , A61P37/06 , C07K14/5406 , C07K14/55 , C07K16/10 , C07K16/1045 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K16/464 , A61K38/00 , A61K2039/505 , A61K2039/545 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/30
摘要： The application relates to a dual cytokine fusion protein composition, pharmaceutical composition, and/or formulation thereof comprising IL-10 or IL-10 variant molecules fused to a single chain variable fragment scaffolding system and a second cytokine, where the second cytokine is linked in the hinge region of the scFv. The application also relates to methods of using the dual cytokine fusion protein composition for treating cancer, inflammatory diseases or disorders, and immune and immune mediated diseases or disorders.
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4.发明公开公开(公告)号：US20240307446A1
公开(公告)日：2024-09-19
申请号：US18605746
申请日：2024-03-14
IPC分类号： A61K35/17 , A61K39/00 , A61P11/00 , C07K14/475 , C07K14/54 , C07K14/705 , C07K14/715 , C12N5/071 , C12N5/0783
CPC分类号： A61K35/17 , A61K39/4612 , A61K39/46441 , A61K39/464419 , A61K39/464429 , A61K39/46444 , A61P11/00 , C07K14/4753 , C07K14/5428 , C07K14/70596 , C07K14/7155 , C12N5/0646 , C12N5/0688
摘要： B cell subsets, generation of B cell subsets and utilization of B cell subsets for treatment of Chronic Obstructive Pulmonary Disease (COPD). In one embodiment B cells possessing a B regulatory phenotype are generated in vivo by administrating of mesenchymal stem cells. In another embodiment B regulatory cells are utilized to treat COPD in an interleukin-35 dependent manner. In another embodiment B regulatory cells possess the marker CD5 and produce interleukin-10.
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公开(公告)号：US12065473B2
公开(公告)日：2024-08-20
申请号：US18501581
申请日：2023-11-03
发明人： John Mumm
IPC分类号： C07K14/54 , A61K38/00 , A61K39/395 , A61P35/00 , A61P37/06 , C07K14/55 , C07K16/10 , C07K16/28 , C07K16/32 , C07K16/46 , A61K39/00
CPC分类号： C07K14/5428 , A61P35/00 , A61P37/06 , C07K14/5406 , C07K14/55 , C07K16/10 , C07K16/1045 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K16/464 , A61K38/00 , A61K2039/505 , A61K2039/545 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/30
摘要： The application relates to a dual cytokine fusion protein composition, pharmaceutical composition, and/or formulation thereof comprising IL-10 or IL-10 variant molecules fused to a single chain variable fragment scaffolding system and a second cytokine, where the second cytokine is linked in the hinge region of the scFv. The application also relates to methods of using the dual cytokine fusion protein composition for treating cancer, inflammatory diseases or disorders, and immune and immune mediated diseases or disorders.
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6.发明公开公开(公告)号：US20240271082A1
公开(公告)日：2024-08-15
申请号：US18568774
申请日：2022-06-10
申请人： Fzata, Inc.
发明人： Hua Yu , Lydia Nyasae , Kyle Hoban , Zhiyong Yang
IPC分类号： C12N1/18 , A61K38/00 , A61K39/00 , A61P31/04 , C07K14/54 , C07K14/575 , C07K16/12 , C07K16/24 , C12N15/81
CPC分类号： C12N1/185 , A61P31/04 , C07K14/5428 , C07K14/5759 , C07K16/1282 , C07K16/241 , C07K16/244 , C12N15/81 , A61K38/00 , A61K2039/505 , C07K2317/22 , C07K2317/31 , C07K2317/52 , C07K2317/569 , C07K2317/76 , C12N2510/00
摘要： The disclosure relates to engineered strains of yeast that express a therapeutic polypeptide(s) and/or comprise a nucleic acid encoding a therapeutic polypeptide(s), as well as methods and uses for the same.
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公开(公告)号：US20240207372A1
公开(公告)日：2024-06-27
申请号：US18361724
申请日：2023-07-28
发明人： Randall J. Mrsny , Tahir Mahmood
IPC分类号： A61K38/45 , A61K38/16 , A61K38/17 , A61K38/20 , A61K38/26 , A61K38/27 , A61K38/48 , A61K38/49 , A61K38/50 , A61K38/51 , C07K14/54 , C07K16/24
CPC分类号： A61K38/45 , A61K38/164 , A61K38/166 , A61K38/1793 , A61K38/20 , A61K38/2066 , A61K38/26 , A61K38/27 , A61K38/482 , A61K38/49 , A61K38/50 , A61K38/51 , C07K14/5428 , C07K16/241 , C12Y204/02036 , C12Y304/21068 , C12Y304/21073 , C12Y305/04004 , C12Y402/02001 , C07K2317/76 , C07K2319/00 , C07K2319/21 , C07K2319/30 , C07K2319/32 , C07K2319/50 , C07K2319/55 , C07K2319/60 , C07K2319/90
摘要： The present disclosure relates to pharmaceutical compositions comprising a non-naturally occurring fusion molecule and one or more pharmaceutically acceptable carriers, formulated for oral delivery to a subject, and designed to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases, autoimmune diseases, cancer, metabolic disorders, and growth deficiency disorders. The present disclosure relates to a non-toxic mutant form of the Vibrio cholera Cholix gene (ntCholix), a variant of Cholix truncated at amino acid A386 (Cholix386) and the use of other various Cholix-derived polypeptide sequences to enhance intestinal delivery of biologically-active therapeutics. The systems and methods described herein provide for: the ability to deliver macromolecule doses without injections; the ability to deliver cargo such as siRNA or antisense molecules into intracellular compartments where their activity is required; and the delivery of nanoparticles and dendrimer-based carriers across biological membranes.
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公开(公告)号：US12006346B2
公开(公告)日：2024-06-11
申请号：US18501762
申请日：2023-11-03
发明人： John Mumm
IPC分类号： C07K14/54 , A61K38/00 , A61K39/395 , A61P35/00 , A61P37/06 , C07K14/55 , C07K16/10 , C07K16/28 , C07K16/32 , C07K16/46 , A61K39/00
CPC分类号： C07K14/5428 , A61P35/00 , A61P37/06 , C07K14/5406 , C07K14/55 , C07K16/10 , C07K16/1045 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K16/464 , A61K38/00 , A61K2039/505 , A61K2039/545 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/30
摘要： The application relates to a dual cytokine fusion protein composition, pharmaceutical composition, and/or formulation thereof comprising IL-10 or IL-10 variant molecules fused to a single chain variable fragment scaffolding system and a second cytokine, where the second cytokine is linked in the hinge region of the scFv. The application also relates to methods of using the dual cytokine fusion protein composition for treating cancer, inflammatory diseases or disorders, and immune and immune mediated diseases or disorders.
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公开(公告)号：US11957734B2
公开(公告)日：2024-04-16
申请号：US17301123
申请日：2021-03-25
发明人： SangKon Oh , Sandra Zurawski , Hyemee Joo , Gerard Zurawski
CPC分类号： A61K38/2066 , A61K39/0008 , C07K14/5428 , C07K16/2851 , C07K16/2878 , A61K2039/505 , A61K2039/54 , A61K2039/57 , C07K2317/24 , C07K2317/40 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2319/00
摘要： Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.
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公开(公告)号：US20240076336A1
公开(公告)日：2024-03-07
申请号：US18501581
申请日：2023-11-03
发明人： John MUMM
IPC分类号： C07K14/54 , A61P35/00 , A61P37/06 , C07K14/55 , C07K16/10 , C07K16/28 , C07K16/32 , C07K16/46
CPC分类号： C07K14/5428 , A61P35/00 , A61P37/06 , C07K14/5406 , C07K14/55 , C07K16/10 , C07K16/1045 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K16/464 , A61K2039/505 , C07K2317/53 , C07K2317/565 , C07K2317/92
摘要： The application relates to a dual cytokine fusion protein composition, pharmaceutical composition, and/or formulation thereof comprising IL-10 or IL-10 variant molecules fused to a single chain variable fragment scaffolding system and a second cytokine, where the second cytokine is linked in the hinge region of the scFv. The application also relates to methods of using the dual cytokine fusion protein composition for treating cancer, inflammatory diseases or disorders, and immune and immune mediated diseases or disorders.
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