公开(公告)号：US20170183417A1

公开(公告)日：2017-06-29

申请号：US15256194

申请日：2016-09-02

Applicant: AMGEN INC. ,  AMGEN FREMONT INC.

Inventor： William J. BOYLE ,  Francis H. MARTIN ,  Jose R. CORVALAN ,  C. Geoffrey DAVIS

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2875 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.

公开(公告)号：US20140147444A1

公开(公告)日：2014-05-29

申请号：US13830441

申请日：2013-03-14

Applicant: AMGEN INC.

Inventor： Rajendra V. DESHPANDE ,  William J. BOYLE ,  John K. SULLIVAN ,  Anna Hitz

IPC: A61K39/395 ,  A61K45/06 ,  C07K14/52

Abstract: Selective binding agents of osteoprotegerin binding protein (OPGbp) are provided by the invention. More particularly, the invention provides for antibodies and antigen binding domains which selectively bind to OPGbp and may be used to prevent or treat conditions relating to loss of bone mass. Nucleic acid molecules encoding said antibodies and antigen binding domains, and expression vectors and host cells for the production of same are also provided.

Abstract translation: 本发明提供了骨保护蛋白结合蛋白（OPGbp）的选择性结合剂。 更具体地，本发明提供了选择性结合OPGbp的抗体和抗原结合结构域，并且可用于预防或治疗与骨量丧失相关的病症。 还提供了编码所述抗体和抗原结合结构域的核酸分子，以及用于其生产的表达载体和宿主细胞。

公开(公告)号：US20150266952A1

公开(公告)日：2015-09-24

申请号：US14621072

申请日：2015-02-12

Applicant: AMGEN INC. ,  AMGEN FREMONT INC.

Inventor： William J. BOYLE ,  Francis H. MARTIN ,  Jose R. CORVALAN ,  C. Geoffrey DAVIS

IPC: C07K16/24 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2875 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.

Abstract translation: 描述了与骨保护素配体（OPGL）相互作用的抗体。 描述了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。 描述使用OPGL抗体检测样品中OPGL的量的方法。