公开(公告)号：US11912711B2

公开(公告)日：2024-02-27

申请号：US18072505

申请日：2022-11-30

Applicant: AMGEN INC. ,  Vigil Neuroscience, Inc.

Inventor： Lara C. Czabaniuk ,  Timothy Hopper ,  Jonathan B. Houze ,  Jane Panteleev ,  Gwenaella Rescourio ,  Vincent Santora ,  Haoxuan Wang ,  Ryan D. White ,  Alice R. Wong ,  Yongwei Wu ,  Maxence Bos ,  John Mancuso ,  Ivan Franzoni

IPC: C07D475/00 ,  A61P25/28 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D487/04 ,  A61P25/28 ,  C07D413/14 ,  C07D471/04 ,  C07D475/00

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”).




This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

公开(公告)号：US11884675B2

公开(公告)日：2024-01-30

申请号：US18072501

申请日：2022-11-30

Applicant: AMGEN INC. ,  Vigil Neuroscience, Inc.

Inventor： Lara C. Czabaniuk ,  Timothy Hopper ,  Jonathan B. Houze ,  Jane Panteleev ,  Gwenaella Rescourio ,  Vincent Santora ,  Haoxuan Wang ,  Ryan D. White ,  Alice R. Wong ,  Yongwei Wu ,  Maxence Bos ,  John Mancuso ,  Ivan Franzoni

IPC: C07D487/04 ,  A61P25/28 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D487/04 ,  A61P25/28 ,  C07D413/14 ,  C07D471/04

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”).




This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

公开(公告)号：US11718617B2

公开(公告)日：2023-08-08

申请号：US18072497

申请日：2022-11-30

Applicant: AMGEN INC. ,  Vigil Neuroscience, Inc.

Inventor： Lara C. Czabaniuk ,  Timothy Hopper ,  Jonathan B. Houze ,  Gwenaella Rescourio ,  Vincent Santora ,  Haoxuan Wang ,  Ryan D. White ,  Alice R. Wong ,  Yongwei Wu

IPC: C07D471/04 ,  C07D413/14

CPC classification number: C07D471/04 ,  C07D413/14

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”).




This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

公开(公告)号：US11608344B2

公开(公告)日：2023-03-21

申请号：US17302502

申请日：2021-05-04

Applicant: AMGEN INC. ,  Vigil Neuroscience, Inc.

Inventor： Lara C. Czabaniuk ,  Timothy Hopper ,  Jonathan B. Houze ,  Jane Panteleev ,  Gwenaella Rescourio ,  Vincent Santora ,  Haoxuan Wang ,  Ryan D. White ,  Alice R. Wong ,  Yongwei Wu ,  Maxence Bos ,  John Mancuso ,  Ivan Franzoni

IPC: C07D487/04 ,  C07D413/14 ,  C07D471/04 ,  A61P25/28

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

公开(公告)号：US12252489B2

公开(公告)日：2025-03-18

申请号：US17923160

申请日：2021-05-04

Applicant: AMGEN INC. ,  VIGIL NEUROSCIENCE, INC.

Inventor： Lara C. Czabaniuk ,  Timothy Hopper ,  Jonathan B. Houze ,  Gwenaella Rescourio ,  Vincent Santora ,  Haoxuan Wang ,  Ryan D. White ,  Alice R. Wong ,  Yongwei Wu

IPC: C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  C07D413/14 ,  C07D519/00

Abstract: The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (1).

公开(公告)号：US20230295170A1

公开(公告)日：2023-09-21

申请号：US18072505

申请日：2022-11-30

Applicant: AMGEN INC. ,  Vigil Neuroscience, Inc.

Inventor： Lara C. CZABANIUK ,  Timothy Hopper ,  Jonathan B. Houze ,  Jane Panteleev ,  Gwenaella Rescourio ,  Vincent Santora ,  Haoxuan Wang ,  Ryan D. White ,  Alice R. Wong ,  Yongwei Wu ,  Maxence Bos ,  John Mancuso ,  Ivan Franzoni

IPC: C07D487/04 ,  A61P25/28 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D487/04 ,  A61P25/28 ,  C07D413/14 ,  C07D471/04

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”).




This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

公开(公告)号：US11572374B2

公开(公告)日：2023-02-07

申请号：US17266466

申请日：2019-08-13

Applicant: Amgen Inc. ,  Carmot Therapeutics, Inc.

Inventor： John R. Butler ,  Daniel Erlanson ,  Russell Graceffa ,  Jeffrey Iwig ,  Joon Won Jeong ,  Ryan D. White ,  Yongwei Wu ,  Shuyan Yi ,  Xiao Mei Zheng ,  Jesse M. McFarland ,  Abhisek Banerjee

IPC: C07D519/00 ,  C07D487/18

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.