公开(公告)号：US20240209078A1

公开(公告)日：2024-06-27

申请号：US18251196

申请日：2021-11-08

申请人： AMGEN INC. ,  AMGEN RESEARCH (MUNICH) GMBH

发明人： Stephanie Everts ,  Matthias Klinger ,  Virginie Naegele ,  Adam Zalewski ,  Claudia Blümel ,  Thomas Boehm ,  Johannes Brozy ,  Igor D'Angelo ,  Peter Kufer ,  Petra Lutterbüse ,  Markus Muenz ,  Doris Rau ,  Tobias Raum ,  Benno Rattel ,  Oliver Thomas ,  Ines Ullrich ,  Joachim Wahl ,  Christian Webhofer ,  Sascha Weidler ,  Elizabeth Dang Pham ,  Julie Bailis

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/00

CPC分类号： C07K16/28 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/92

摘要： The present invention provides multitargeting bispecific antigen-binding molecules characterized by comprising a first and a second bispecific entity each comprising a domain binding to target, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain, wherein both bispecific entities are linked to each other by a spacer which spaces apart the first and the second bispecific entity. Moreover, the invention provides a polynucleotide, encoding the multitargeting bispecific antigen-binding molecule, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

公开(公告)号：US20220403035A1

公开(公告)日：2022-12-22

申请号：US17774232

申请日：2020-11-06

申请人： AMGEN RESEARCH ( MUNICH) GMBH ,  AMGEN INC.

发明人： Jonas Anlahr ,  Tara Arvedson ,  Julie Bailis ,  Matthew Chun ,  Igor D'Angelo ,  Christopher Dahlhoff ,  Stephanie Everts ,  Mattias Friedrich ,  Lars Gaedtke ,  Patrick Hoffmann ,  Rebecca Goldstein ,  Jonas Karl-Josef Honer ,  Roman Kischel ,  Matthias Klinger ,  Peter Kufer ,  Markus Muenz

IPC分类号： C07K16/28

摘要： The present invention provides bispecific antigen-binding molecules characterized by comprising a first and a second domain, each binding to any of CS1, BCMA, CD20, CD22, FLT3, CD123, CLL1, MSLN, CDH3 or EpCAM, a third domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and optionally a fourth domain, which is a Fc modality. Moreover, the invention provides a polynucleotide, encoding the antigen-binding molecule, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.