公开(公告)号：US20220403035A1

公开(公告)日：2022-12-22

申请号：US17774232

申请日：2020-11-06

申请人： AMGEN RESEARCH ( MUNICH) GMBH ,  AMGEN INC.

发明人： Jonas Anlahr ,  Tara Arvedson ,  Julie Bailis ,  Matthew Chun ,  Igor D'Angelo ,  Christopher Dahlhoff ,  Stephanie Everts ,  Mattias Friedrich ,  Lars Gaedtke ,  Patrick Hoffmann ,  Rebecca Goldstein ,  Jonas Karl-Josef Honer ,  Roman Kischel ,  Matthias Klinger ,  Peter Kufer ,  Markus Muenz

IPC分类号： C07K16/28

摘要： The present invention provides bispecific antigen-binding molecules characterized by comprising a first and a second domain, each binding to any of CS1, BCMA, CD20, CD22, FLT3, CD123, CLL1, MSLN, CDH3 or EpCAM, a third domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and optionally a fourth domain, which is a Fc modality. Moreover, the invention provides a polynucleotide, encoding the antigen-binding molecule, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.