公开(公告)号：US20190167745A1

公开(公告)日：2019-06-06

申请号：US16266658

申请日：2019-02-04

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyun J. Shin ,  Jin Kwan KIM ,  Chae Wook KIM ,  Kyung Mi JOO ,  Yeon Su JEONG ,  Kyung Min LIM ,  Dae-Bang SEO ,  Yung Hyup JOO ,  Sang Jun LEE ,  Young-Ho PARK

IPC: A61K36/48 ,  A23L33/105 ,  A23L2/52

Abstract: The present invention relates to a composition containing a bean extract extracted by low-concentration, low-grade alcohol or fractions thereof. The composition exhibits excellent effects in improving blood circulation, improving obesity, and preventing diabetes, hyperlipidemia and the like, and exhibits the effects of alleviating or treating the symptoms of diabetes, hyperlipidemia, and the like. The present invention also relates to a method for improving blood circulation and vascular health.

公开(公告)号：US20140011881A1

公开(公告)日：2014-01-09

申请号：US14022789

申请日：2013-09-10

Applicant: Amorepacific Corporation

Inventor： Song Seok SHIN ,  Jin Kwan KIM ,  Sun-Young KIM ,  Ki-Wha LEE ,  Byoung young WOO ,  Joo-Hyun MOH ,  Yeon Su JEONG ,  Kyung Min LIM ,  Jin Kyu CHOI ,  Hyun-Ju KOH ,  Young-Ho PARK

IPC: C07C311/08

CPC classification number: C07C311/08 ,  C07C2601/14 ,  C07D295/145

Abstract: This present disclosure relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same.The present disclosure provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

Abstract translation: 本公开涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanilloid Receptor 1; VR1; TRPV1）拮抗剂; 和含有该组合物的药物组合物。 本公开提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼或粘膜，胃十二指肠溃疡，炎性疾病，耳病，心脏病等。