公开(公告)号：US20180179146A1

公开(公告)日：2018-06-28

申请号：US15736406

申请日：2016-06-03

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Heung Soo BAEK ,  Yong Jin KIM ,  Hong-Ju SHIN ,  John Hwan LEE

IPC: C07C231/02

Abstract: The present invention relates to a method for preparing a benzoic acid amide compound in a high yield by presenting a novel method for preparing a benzyl amine compound to be used as a reactant and delimiting the reaction condition of each step by using the same, and the method is economically advantageous since mass production is possible.

公开(公告)号：US20180267022A1

公开(公告)日：2018-09-20

申请号：US15542263

申请日：2016-02-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Chang Seok LEE ,  Heung Soo BAEK ,  Yung Hyup JOO ,  Jeong Hwan KIM ,  Hong-Ju SHIN ,  Mi Young PARK ,  Song Seok SHIN

IPC: G01N33/50

CPC classification number: G01N33/5044 ,  G01N33/5014

Abstract: In one aspect of the present specification, provided is a method for predicting a side effect of a whitening ingredient, the method comprising measuring at least one of i) the increase in toxicity according to long-term use of a whitening ingredient, ii) the difference between a concentration having whitening effect and a concentration having cell toxicity, and iii) the increase in sensitivity to the whitening ingredient according to ultraviolet pretreatment. In addition, the method has an effect of effectively predicting whether a side effect will occur if the whitening ingredient is used for a long time.

公开(公告)号：US20180065922A1

公开(公告)日：2018-03-08

申请号：US15561585

申请日：2016-03-30

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Soo Jeong CHOI ,  Heung Soo BAEK ,  Chang Seok LEE ,  Jeong Hwan KIM ,  Yongjin KIM ,  Hong-Ju SHIN ,  Ho Sik RHO ,  Song Seok SHIN ,  Jon Hwan LEE

IPC: C07C233/70 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02

CPC classification number: C07C233/70 ,  A23L29/00 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02 ,  C07C231/12 ,  C07C235/48

Abstract: Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.

公开(公告)号：US20190010137A1

公开(公告)日：2019-01-10

申请号：US16064764

申请日：2016-12-15

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Jae Won YOO ,  Yong Jin KIM ,  Ho Sik RHO ,  John Hwan LEE

IPC: C07D311/72 ,  A61Q19/00 ,  A61Q17/00 ,  A61K8/68

Abstract: The present invention relates to a pseudo-ceramide compound and a method for preparing the same. The pseudo-ceramide compound of the present invention may provide antioxidant effects, and exhibits improved properties such as high solubility compared to existing natural ceramides and pseudo-ceramide compounds, and therefore, may be included in large quantities in the formulation. Accordingly, the pseudo-ceramide compound may be used in various fields such as cosmetics, medicinal substances, external preparations and foods.

公开(公告)号：US20170283347A1

公开(公告)日：2017-10-05

申请号：US15506972

申请日：2015-08-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Song Seok SHIN ,  Byoung Young WOO ,  Heung Soo BAEK ,  Yong Deog HONG ,  Hong-Ju SHIN ,  Yeon Su JEONG ,  Jon Hwan LEE

IPC: C07C13/615 ,  C07C233/57 ,  C07C15/04

Abstract: Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

公开(公告)号：US20170312230A1

公开(公告)日：2017-11-02

申请号：US15518428

申请日：2015-10-21

Applicant: Amorepacific Corporation

Inventor： Heung Soo BAEK ,  Byeong Yung WOO ,  Se Jin YOO ,  Yung Hyup JOO ,  Song Seok SHIN ,  Mi Hyun OH ,  John Hwan LEE ,  Seo Young KIM

IPC: A61K31/047 ,  A61Q19/10 ,  A61K8/34

CPC classification number: A61K31/047 ,  A61K8/30 ,  A61K8/34 ,  A61Q19/10

Abstract: The present invention relates to a composition which can effectively control bacteria by containing meso-2,3-butanediol, which is an isomer of 2,3-butane diol, and has excellent antiseptic power even without containing a chemical antiseptic agent.

公开(公告)号：US20190248736A1

公开(公告)日：2019-08-15

申请号：US16336893

申请日：2017-09-14

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Jae Won YOO ,  Yong Jin KIM ,  Ho Sik RHO ,  John Hwan LEE

IPC: C07C235/06 ,  C07C231/02 ,  C07B51/00

Abstract: The present invention relates to a pseudo-ceramide compound and a preparation method therefor. According to the present invention, the pseudo-ceramide compound has a molecular structure and a function similar to those of a natural ceramide, can be readily synthesized, and has excellent solubility in an organic solvent and excellent stability, and thus the pseudo-ceramide compound can be used as an alternative to a natural ceramide. Therefore, the pseudo-ceramide compound of the present invention can be widely applied to a skin preparation for external use, a cosmetic composition, and the like for reinforcing and maintaining a skin barrier function.

公开(公告)号：US20190167745A1

公开(公告)日：2019-06-06

申请号：US16266658

申请日：2019-02-04

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyun J. Shin ,  Jin Kwan KIM ,  Chae Wook KIM ,  Kyung Mi JOO ,  Yeon Su JEONG ,  Kyung Min LIM ,  Dae-Bang SEO ,  Yung Hyup JOO ,  Sang Jun LEE ,  Young-Ho PARK

IPC: A61K36/48 ,  A23L33/105 ,  A23L2/52

Abstract: The present invention relates to a composition containing a bean extract extracted by low-concentration, low-grade alcohol or fractions thereof. The composition exhibits excellent effects in improving blood circulation, improving obesity, and preventing diabetes, hyperlipidemia and the like, and exhibits the effects of alleviating or treating the symptoms of diabetes, hyperlipidemia, and the like. The present invention also relates to a method for improving blood circulation and vascular health.

公开(公告)号：US20180116933A1

公开(公告)日：2018-05-03

申请号：US15561428

申请日：2016-03-29

Applicant: Amorepacific Corporation

Inventor： Yung Hyup JOO ,  Heung Soo BAEK ,  Jeong Ah HWANG ,  Hae Kwang LEE ,  Yongjin KIM ,  Hong-Ju SHIN ,  Jon Hwan LEE

IPC: A61K8/42 ,  A61Q19/08 ,  A61K31/166 ,  A23L33/00 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L2/52

CPC classification number: A61K8/42 ,  A23L2/52 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/30 ,  A23V2002/00 ,  A61K8/30 ,  A61K8/34 ,  A61K31/166 ,  A61Q19/08

Abstract: 5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present specification can exhibit excellent anti-oxidative and anti-aging effects while having no toxicity. For example, the compound exhibits excellent anti-oxidative and anti-aging effects by scavenging free radicals or inhibiting MMP-1 expression.