公开(公告)号：US20190022133A1

公开(公告)日：2019-01-24

申请号：US16050651

申请日：2018-07-31

Applicant: AMORPHICAL LTD.

Inventor： Amir SAGI ,  Assaf SHECHTER ,  Galit SHALTIEL-GOLD ,  Michal DANIELY ,  Oren MEIRON

IPC: A61K33/10 ,  A61K31/663 ,  A61K35/612

Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.

公开(公告)号：US20150374747A1

公开(公告)日：2015-12-31

申请号：US14766716

申请日：2014-02-10

Applicant: AMORPHICAL LTD.

Inventor： Oren MEIRON ,  Galit SHALTIEL-GOLD ,  Michal DANIELY

IPC: A61K33/10 ,  A61K45/06 ,  A61K47/12 ,  A61K47/36 ,  A61K47/26 ,  A61K9/00 ,  A61K47/24

CPC classification number: A61K33/10 ,  A61K9/0053 ,  A61K31/122 ,  A61K31/355 ,  A61K31/375 ,  A61K45/06 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  A61K47/36 ,  A61K2300/00

Abstract: The present invention provides a method for accelerating bone growth in a subject having a bone condition, selected from the group consisting of a fracture by external force, pathological fracture, fatigue fracture, distraction osteogenesis, osteotomy, osseointegration and combinations thereof, the method employing the administration of a composition containing stable amorphous calcium carbonate, comprising at least one stabilizer. Further provided are the orally-administrable pharmaceutical compositions for use in accelerating bone growth in said bone conditions.

Abstract translation: 本发明提供一种用于加速受试者骨骼生长的方法，所述骨骼状况选自由外力断裂，病理性骨折，疲劳断裂，牵引成骨，截骨，骨整合及其组合组成的组，其采用 施用包含稳定的无定形碳酸钙的组合物，其包含至少一种稳定剂。 还提供了用于在所述骨骼状况下促进骨生长的可口服给药的药物组合物。