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    Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use
    1.
    发明授权
    Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use 有权

    公开(公告)号：US10463762B2

    公开(公告)日：2019-11-05

    申请号：US15356885

    申请日：2016-11-21

    申请人： ANTEIS S.A.

    发明人： Samuel Gavard Molliard

    IPC分类号： A61L27/20 ,  A61L27/58 ,  A61L27/54 ,  A61L27/10 ,  A61L27/52 ,  A61L27/12

    摘要： The object of the present invention is an injectable sterile aqueous formulation, ready-to-use, resorbable, used for aesthetic purposes as a particulate, cohesive, viscoelastic gel comprising i) crosslinked hyaluronic acid, or one of its salts, at a concentration of between 0.1% and 4% (mass/volume); the crosslinking carried out providing the possibility of obtaining a gel based on crosslinked hyaluronic acid with a so-called cohesive structure, and ii) hydroxyapatite, at a concentration of between 5% and 60% (mass/volume), the hydroxyapatite being in the form of particles with an average size of less than or equal to 200 μm; the injectable sterile aqueous formulation having viscoelastic properties such that tan δ at the frequency of 1 Hz is less than or equal to 0.60.

    INJECTABLE STERILE AQUEOUS FORMULATION BASED ON CROSSLINKED HYALURONIC ACID AND HYDROXYAPATITE FOR AESTHETIC USE
    2.
    发明申请
    INJECTABLE STERILE AQUEOUS FORMULATION BASED ON CROSSLINKED HYALURONIC ACID AND HYDROXYAPATITE FOR AESTHETIC USE 审中-公开
    基于交联羟丙酸和羟丙酸的美容方法的无效水性配方

    公开(公告)号：US20150257989A1

    公开(公告)日：2015-09-17

    申请号：US14433927

    申请日：2013-09-24

    申请人： ANTEIS S.A.

    发明人： Samuel Gavard Molliard

    IPC分类号： A61K8/04 ,  A61K8/24 ,  A61Q19/08 ,  A61K8/73

    CPC分类号： A61K8/042 ,  A61K8/0241 ,  A61K8/24 ,  A61K8/735 ,  A61K2800/54 ,  A61K2800/91 ,  A61Q19/08

    摘要： The object of the present invention is an injectable sterile aqueous formulation, ready-to-use, resorbable, used for aesthetic purposes as a particulate, cohesive, viscoelastic gel comprising i) crosslinked hyaluronic acid, or one of its salts, at a concentration of between 1% and 4% (mass/volume); the crosslinking carried out providing the possibility of obtaining a gel based on crosslinked hyaluronic acid with a so-called cohesive structure, and ii) hydroxyapatite, at a concentration of between 5% and 60% (mass/volume), the hydroxyapatite being in the form of particles with an average size of less than or equal to 200 μm; the injectable sterile aqueous formulation having viscoelastic properties such that tan δ at the frequency of 1 Hz is less than or equal to 0.60.

    摘要翻译： 本发明的目的是一种可注射无菌水性制剂，即可使用，可再吸收，作为颗粒状，粘性粘弹性凝胶用作美学目的，包括i）交联透明质酸或其盐之一，浓度为 1％至4％（质量/体积）; 进行的交联提供了获得基于具有所谓的内聚结构的交联透明质酸的凝胶的可能性，和ii）羟基磷灰石，浓度为5％至60％（质量/体积），羟基磷灰石位于 平均尺寸小于或等于200μm的颗粒形式; 具有粘弹性的注射无菌水性制剂使1Hz频率下的tanδ小于或等于0.60。

    Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use
    3.
    发明授权
    Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use 有权

    公开(公告)号：US10434040B2

    公开(公告)日：2019-10-08

    申请号：US15941735

    申请日：2018-03-30

    申请人： ANTEIS S.A.

    发明人： Samuel Gavard Molliard

    IPC分类号： A61K8/02 ,  A61K8/04 ,  A61K8/24 ,  A61K8/73 ,  A61Q19/08

    摘要： The object of the present invention is an injectable sterile aqueous formulation, ready-to-use, resorbable, used for aesthetic purposes as a particulate, cohesive, viscoelastic gel comprising i) crosslinked hyaluronic acid, or one of its salts, at a concentration of between 0.1% and 4% (mass/volume); the crosslinking carried out providing the possibility of obtaining a gel based on crosslinked hyaluronic acid with a so-called cohesive structure, and ii) hydroxyapatite, at a concentration of between more than 70% and 140% (mass/volume), said hydroxyapatite being in the form of particles with an average size of less than or equal to 200 μm; said injectable sterile aqueous formulation having viscoelastic properties such that tan δ at the frequency of 1 Hz is less than or equal to 0.60.