专利检索 ap:("ARBOR PHARMACEUTICALS, LLC") AND inv:"Mark A. Gallop" 第 1 页

1.

发明授权
Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 有权

公开(公告)号：US10385014B2

公开(公告)日：2019-08-20

申请号：US15914621

申请日：2018-03-07

申请人： ARBOR PHARMACEUTICALS, LLC

发明人： Mark A. Gallop , Fenmei Yao , Maria J. Ludwikow , Thu Phan , Ge Peng

IPC分类号： C07C269/06 , C07C271/22 , C07D213/79 , C07D307/30 , C07D333/32 , C07D333/38 , C07D307/68 , A61K31/27

摘要： The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.