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公开(公告)号：US11045472B2
公开(公告)日：2021-06-29
申请号：US16610812
申请日：2018-05-03
发明人： Manmohan Reddy Leleti , Dillon Harding Miles , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif , Rhiannon Thomas-Tran
IPC分类号： C07D401/14 , C07D405/14 , A61K31/517 , A61K33/243 , A61K31/4709 , A61K31/704 , A61K39/395 , A61K45/06
摘要： Compounds of Formula I that inhibit at least one of the A2A and A2B adenosine receptors, and compositions containing compounds of Formula I and methods for synthesizing compounds of Formula I, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.
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公开(公告)号：US11072597B2
公开(公告)日：2021-07-27
申请号：US16460263
申请日：2019-07-02
发明人： Joel Beatty , Laurent Debien , Jenna Jeffrey , Manmohan Reddy Leleti , Debashis Mandal , Dillon Miles , Jay Powers , Brandon Rosen , Ehesan Sharif , Rhiannon Thomas-Tran
IPC分类号： C07D403/00 , C07D401/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D417/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D403/04
摘要： Compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.
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公开(公告)号：US10399962B2
公开(公告)日：2019-09-03
申请号：US15875106
申请日：2018-01-19
发明人： Joel Beatty , Laurent Debien , Jenna Jeffrey , Manmohan Reddy Leleti , Debashis Mandal , Dillon Miles , Jay Powers , Brandon Rosen , Ehesan Sharif , Rhiannon Thomas-Tran
IPC分类号： C07D405/00 , A61K31/505 , C07D401/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.
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公开(公告)号：US11931343B2
公开(公告)日：2024-03-19
申请号：US17271795
申请日：2019-08-26
发明人： Joel Beatty , Laurent Pierre Paul Debien , Samuel Lawrie Drew , Jeremy Fournier , Rebecca Louise Grange , Steven Donald Jacob , Jenna Leigh Jeffrey , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Debashis Mandal , Jay Patrick Powers , Anh Thu Tran , Rhiannon Thomas-Tran , Xuelei Yan
IPC分类号： A61K31/4192 , A61K31/282 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/519 , A61K31/704 , A61K33/243 , A61K39/395 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04
CPC分类号： A61K31/4192 , A61K31/282 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/519 , A61K31/704 , A61K33/243 , A61K39/3955 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04
摘要： Compounds, such as compounds having Formula (I):
wherein each variable is as described herein, that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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